Antibody

α-Tubulin (DM1A)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IC, IH
Source: Sigma Aldrich
Cat# F2168
References:
Frost, 2009
Tatebayashi, 2002
Stamer, 2002
Lee, 2002
Formulation: protein-A purified, gel filtered, PBS, BSA, azide, FITC conj.
Reactivity:
Reacts in: Amphibian (various), Bovine, Goat, Chicken, Sea Urchin, Fungi, Yeast, Kangaroo, Human, Monkey, Gerbil, Hamster, Mouse, Rat, Nicotiana tabacum, Trypanosome

Immunogen/Epitope

immunogen = purified chick brain microtubules (epitope in the C-terminal of α-tubulin)

Specificity

detects the carboxy-terminal part of alpha-tubulin

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References

Paper Citations

  1. . Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem. 2009 May 8;284(19):12845-52. PubMed.
  2. . Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. PubMed.
  3. . Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol. 2002 Mar 18;156(6):1051-63. PubMed.
  4. . Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch. J Biol Chem. 2002 Nov 22;277(47):45013-9. PubMed.

Further Reading

No Available Further Reading