TDP-43 phos Ser409/410 (1D3, 7A9)


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Clonality: monoclonal
Host: Rat
Isotype: IgG2a
Methods: ELISA, IB, IH, WB
Source: Manuela Neumann
Formulation: Cell culture supernatant
Reacts in: Human, Mouse
Availability: Confirmed available Oct 2014


immunogen = phosphopeptide pS409/410 (SMDSKS(p)S(p)GWG), corresponding to amino acids 404-413 of human TDP-43, coupled to BSA or ovalbumin.


Detects C-terminal TDP-43 phosphorylated at serine 409 and 410. Does not react with the non-phosphorylated protein. By immunohistochemistry, labels a variety of TDP-43  inclusions, including neuronal cytoplasmic inclusions, dystrophic neurites, neuronal intranucelar inclusions, and glial cytoplasmic inclusions.

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Further Reading


  1. . Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. J Biol Chem. 2009 Mar 27;284(13):8516-24. Epub 2009 Jan 21 PubMed.
  2. . Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem. 2009 Aug;110(3):1082-94. Epub 2009 Jun 9 PubMed.
  3. . Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Arch Neurol. 2009 Dec;66(12):1483-8. PubMed.
  4. . Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol. 2013 Dec;126(6):859-79. Epub 2013 Oct 6 PubMed.
  5. . Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. J Clin Invest. 2011 Feb;121(2):726-38. Epub 2011 Jan 4 PubMed.
  6. . The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science. 2013 Mar 15;339(6125):1335-8. Epub 2013 Feb 7 PubMed.