Methods: IB, IF, IH
Source: C-terminal antibody
(Virginia M.-Y. Lee, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine)
Reacts in: Human, Mouse
immunogen = phosphopeptide pS409/410 (SMDSKS(p)S(p)GWG), corresp. to amino acid residues 404-413 of human TDP-43, coupled to BSA or ovalbumin.
detects C-terminal TDP-43 phosphorylated at Serine 409 and 410, not with the non- phosphorylated peptide and not with physiologic TDP-43; labels all types of pathologic inclusions, such as NCI, CGIs, NII, DN previously described with phosphorylation-independent TDP-43 antibodies
- Gijselinck I, Engelborghs S, Maes G, Cuijt I, Peeters K, Mattheijssens M, Joris G, Cras P, Martin JJ, De Deyn PP, Kumar-Singh S, Van Broeckhoven C, Cruts M. Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2010 May;67(5):606-16. PubMed.
No Available Further Reading