Methods: IF, IH, WB
(Vincent L. Cryns, Cell Death Regulation Laboratory, Division of Endocrinology, Metabolism, and Molecular Medicine, Northwestern University, Chicago, IL)
Formulation: purified IgG, HEPES, saline, glycerol.
Reacts in: Human
immunogen = KLH- C S S T G S I D M V D, corresp. to residues 412-421 at the C-terminus of tau truncated at Asp421
recognizes tau when truncated at Asp421; no reaction with full-length tau, or with tau truncated at Glu391 or Ala429
- Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem. 2010 Oct 1;285(40):30851-60. PubMed.
No Available Further Reading