Antibody

Tau phos Ser235 (MC6)

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Clonality: monoclonal
Host: Mouse
Source: MC6
(Gregory Jicha, Departments of Pathology and Neurpscience, Albert Einstein College of Medicine)
References:
Vingtdeux, 2010
Planel, 2008
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = affinity purified PHF (epitope around phosphor. Ser235)

Specificity

recognizes tau phosphor. at Ser235; not reactive to non-phosphor. tau.paper Jincha, et al. 1997

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References

Paper Citations

  1. Vingtdeux V, Davies P, Dickson DW, Marambaud P. AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol. 2011 Mar;121(3):337-49. PubMed.
  2. Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. J Neurosci. 2008 Nov 26;28(48):12798-807. PubMed.

External Citations

  1. Jincha, et al.

Further Reading

No Available Further Reading