Antibody

Tau (HT7)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: ELISA, IH, WB
Source: Pierce Thermo Scientific
Cat# MN-1000
References:
Zhang Y, 2010
van Eersel, 2010
Ittner, 2010
Wang, J, 2010
Clavaguera, 2009
Luo, 2007
Eckermann, 2007
Formulation: serum-free supernatant, affinity purified, no carrier or preservative<br />Also available Biotin conj, MN-1000B
Reactivity:
Reacts in: Bovine, Human
<em>not</em> rat

Immunogen/Epitope

immunogen = purified human tau, between aa 159 and 163, (PPGQK)

Specificity

tau and PHF tau from human and bovine brain

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References

Paper Citations

  1. . Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19014-9. PubMed.
  2. . Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13888-93. PubMed.
  3. . Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell. 2010 Aug 6;142(3):387-97. PubMed.
  4. . Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6498-503. PubMed.
  5. . Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol. 2009 Jul;11(7):909-13. PubMed.
  6. . Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  7. . The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem. 2007 Oct 26;282(43):31755-65. PubMed.

Further Reading

No Available Further Reading