Antibody

Tau (AT270)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: IH, WB
Source: Pierce Thermo Scientific
Cat# MN-1050
References:
van Eersel, 2010
Julien, 2008
Luo, 2007
Shahani, 2006
Formulation: supernatant, affinity purified, no carrier or preservative<br />Also available biotin conj., MN-1050B
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen == partially purified human PHF tau, aa. around phosphorylated Thr181

Specificity

PHF tau, tamgles and neurofilaments; no cross with recomb. unphospho tau; weak cross with normal tau

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References

Paper Citations

  1. . Sodium selenate mitigates tau pathology, neurodegeneration, and functional deficits in Alzheimer's disease models. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13888-93. PubMed.
  2. . High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model. Neurobiol Aging. 2010 Sep;31(9):1516-31. PubMed.
  3. . Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci U S A. 2007 May 29;104(22):9511-6. PubMed.
  4. . Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer's disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci. 2006 May 31;26(22):6103-14. PubMed.

Further Reading

No Available Further Reading