Antibody

Tau (AT180)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, WB
Source: Innogenetics
cat# BR-007
References:
Wang, 2007
Tatebayashi, 2002
Lewis, 2001
Khurana, 2006
Oddo, 2005
distributed by Autogen Bioclear as 90337
Formulation: liquid, PBS, sterile filtered, no preservative, affinity purified
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = human tau40, aa. around phospho.Thr 231

Specificity

PHF tau and tau in tangles; no cross with unphosphorylated tau

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References

Paper Citations

  1. . Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10252-7. PubMed.
  2. . Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13896-901. PubMed.
  3. . Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science. 2001 Aug 24;293(5534):1487-91. PubMed.
  4. . TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006 Feb 7;16(3):230-41. PubMed.
  5. . Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3046-51. PubMed.

Further Reading

No Available Further Reading