Methods: IH, IP, WB
(E-M. Mandelkow, Max-Planck-Unit for Struct. Mol. Biol). This antibody is avaliable from DAKO as A0024
Reacts in: Human
epitope comprises the 4 repeats of Tau, starting at Q244 (preceded by M) and extends to the C-terminus (L441)
recognizes the 4-repeat section of tau; binds very tightly
- Wang YP, Biernat J, Pickhardt M, Mandelkow E, Mandelkow EM. Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10252-7. PubMed.
No Available Further Reading