Antibody

TARDPB /TDP-43 (2E2-D3)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IF, IH, WB
Source: Abnova Corporation
Cat# H00023435-M01
References:
Steinacker, 2008
Zhang, 2008, epitope mapping.
Winton, 2008
Formulation: liquid, PBS
Reactivity:
Reacts in: Human
<em>not</em> mouse or rat

Immunogen/Epitope

immunogen = TARDBP (AAH01487, aa 1 ~261) full length recombinant protein with GST tag. (epitope at aa 205-222)

Specificity

recognizes aa 205–222 of human TDP-43, correspond. to a part of the second RNA recognition motif (RRM2);also recognizes 25 kDa C-terminal fragments

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References

Paper Citations

  1. . TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2008 Nov;65(11):1481-7. PubMed.
  2. . Epitope mapping of 2E2-D3, a monoclonal antibody directed against human TDP-43. Neurosci Lett. 2008 Mar 28;434(2):170-4. PubMed.
  3. . Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008 May 9;283(19):13302-9. PubMed.

Further Reading

No Available Further Reading