Antibody

α-synuclein phos Ser129 (pSyn64)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: IH, WB
Source: Wako Chemicals
Cat# 014-20281
References:
Machiya, 2010
Paleologou, 2010
Ihara, 2007
Reactivity:
Reacts in: Rodent (various), Human

Immunogen/Epitope

immunogen = polypeptide (aa 124-134) including phosphorylated Ser129 of human alpha-Synuclein

Specificity

human alpha-Synuclein including phospho. Ser129; does not cross react with normal human alpha-Synuclein

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References

Paper Citations

  1. . Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner. J Biol Chem. 2010 Dec 24;285(52):40732-44. PubMed.
  2. . Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci. 2010 Mar 3;30(9):3184-98. PubMed.
  3. . Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 2007 Feb 15;53(4):519-33. PubMed.

Further Reading

No Available Further Reading