Antibody

Synaptophysin (SY 38)

Tools

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: IC, WB
Source: Dako
Cat# M0776
References:
(Li H, 2010
Andrews-Zwilling, 2010
Dossena, 2008
Kallhoff, 2007
LaMonte, 2002
all, unspecified formulation)
Formulation: purified ascites, Tris-HCL, BSA, azide.<br />Also available as ready-to-use, IR776; ready-to-use with Dako Autostainer /Autostainer Plus, IS776
Reactivity:
Reacts in: Rabbit, Cow, Human, Guinea Pig, Mouse, Rat

Immunogen/Epitope

immunogen = crude fractions of coated vesicles from bovine brain (located to a pentapeptide repeat structure in the carboxy-terminal cytoplasmic tail of synaptophysin)

Specificity

labels neuronal structures, notably at the synapses; cells display a cytoplasmic staining pattern; useful tool for the identification of a wide spectrum of neuroendocrine neoplasms of the neural type, including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, and paragangliomas.

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References

Paper Citations

  1. . Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17362-7. PubMed.
  2. . Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci. 2010 Oct 13;30(41):13707-17. PubMed.
  3. . Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron. 2008 Nov 26;60(4):598-609. PubMed.
  4. . Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2007;2:6. PubMed.
  5. . Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration. Neuron. 2002 May 30;34(5):715-27. PubMed.

Further Reading

No Available Further Reading