Antibody

soluble Amyloid oligomers

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Clonality: polyclonal
Host: Rabbit
Methods: DB, ELISA, IH, WB
Source: A11
(paper comparing A11 and OC antibodies;
source paper for A11;
Charles G Glabe, University of California, Irvine)
References:
Lefterov, 2010
Formulation: serum
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = soluble Amyloid oligomers

Specificity

generic epitope common to prefibrillar oligomers and not fibrils, monomers or natively folded precursor proteins. Stains small focal or punctuate deposits in AD tissue does not stain diffuse plaques or other plaque types. Stains Ab and polyQ prefibrillar oligomers.

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References

Paper Citations

  1. . Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice. J Biol Chem. 2010 Nov 19;285(47):36945-57. PubMed.

External Citations

  1. paper comparing A11 and OC antibodies
  2. source paper for A11
  3. Charles G Glabe

Further Reading

No Available Further Reading