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Antibodies

168 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
α-, β-, γ-secretase From labs (3)
Ab9B21(SmithKline Beecham Pharmaceuticals, Harlow, UK)Reference: Parkin, 2007 monoclonal
Mouse
IB Human immunogen = BACE1-Fc fusion protein recognizes thecatalytic domain of BACE1; allows detection of soluble shed BACE1 -
anti-M2Reference: Chang, 2007 polyclonal
Goat
(liquid, affinity purified, Alexa 488 conj.)
Block, IF, IS Mouse immunogen = memapsin 2 ectodomain (Paper) Memapsin 2 ectodomain; some cross with memapsin 1 (BACE-2) -
BACE-Cat1Reference: O'Connor, 2008 monoclonal
IgG1
Mouse
(affinity purified)
ELISA, IB, IF, IH Human, Mouse immunogen = N terminus catalytic domain (amino acids 46–460) with N-terminal 6xHis tag recognizes thecatalytic domain of BACE-1.Paper by Zhao et al., 2007 -
α-, β-, γ-secretase From manufacturers (97)
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, BSA, protein A purified)
WB Human immunogen = recombinant full length protein human BACE: solubilized total recombinant protein BACE1; cross-reactivity with BACE2 is almost negligible -
Abcam polyclonal
IgG
Rabbit
(liquid, whole serum, azide)
WB Human immunogen = synthetic peptide (I R L P L R S G L G G A P L G L R L P R) corresp. to aa 26-45 of human BACE1 proBACE; not mature BACE -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human immunogen = synthetic peptide, corr. to aa 441-457 of human BACE2 ~58 kDa BACE2 -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human immunogen = synthetic peptide, corr. to aa 503-518 of human BACE2 ~58 kDa BACE2 -
Abcam polyclonal
IgG
Rabbit
(IgG fraction, affinity purified, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, corr. to aa 496-511 of human BACE2 BACE2 -
Abcam polyclonal
IgG
Rabbit
(IgG fraction, purified, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, corr. to aa 44-59 of human BACE2 BACE2 -
Abcam polyclonal
IgG
Rabbit
(liquid, glyceerol, azide, affinity purified)
WB Human immunogen = synthetic peptide based on cytoplasmic domain of human BACE1 recognizes all four of the splice variants of BACE1 -
Abcam polyclonal
IgG
Rabbit
(liquid, glycerol, azide, affinity purified)
WB Human immunogen = synthetic peptide based on stalk region of human BACE1 recognizes all four of the splice variants of BACE1 -
Abcam polyclonal
IgG
Rabbit
(liquid, glycerol, azide, affinity purified)
WB Human immunogen = synthetic peptide based on catalytic domain of human BACE2 recognizes all three of the splice variants of BACE2. -
Abcam polyclonal
IgG
Rabbit
(liquid, glycerol, azide, affinity purified)
WB Human immunogen = synthetic peptide based on cytoplasmic domain of human BACE2 recognizes the two longest of the splice variants of BACE2 -
Abcam polyclonal
IgG
Rabbit
(liquid, glycerol, azide, affinity purified)
WB Human immunogen = synthetic peptide based on stalk region of human BACE2 recognizes the two longest of the splice variants of BACE2 -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, BSA, PBS, azide)
WB Human immunogen = synthetic peptide, C L R Q Q H D D F A D D I S L L K, aa 458-501 of human BACE Transfected BACE1 -
Abcam polyclonal
IgG
Rabbit
(liquid, whole serum, azide)
IH Human immunogen = synthetic peptide, C L R Q Q H D D F A D D I S L L K, aa 458-501 of human BACE 70 kDa BACE, plasma membrane -
Biomol Enzo Life Sciences polyclonal
Rabbit
(liquid, PBS, glycerol, azide, affinity purified)
IB Human, Mouse, Rat immunogen = synthetic peptide based on the catalytic domain of the human BACE1 seq. recognizes zymogen and mature BACE1; no cross with BACE2 -
Biosource Invitrogen polyclonal
Rabbit
(processed whole serum, azide)
WB Human immunogen = synthetic peptide, corr. to C-terminal 15 residues of human β-secretase 1 proBACE, and mature BACE -
Zymed/ Invitrogen polyclonal
Rabbit
(affinity purified, PBS, azide)
WB Mouse immunogen = synthetic peptide derived from the C-terminal region of human BACE C-terminal region of mouse BACE -
Zymed/ Invitrogen polyclonal
Rabbit
(affinity purified, PBS, azide)
WB Mouse immunogen = synthetic peptide derived from the C-terminal region of human BACE 2 C-terminal region of mouse BACE 2 -
Zymed/ Invitrogen polyclonal
Rabbit
(affinity purified, PBS, azide)
WB Mouse immunogen = synthetic peptide derived from the mid region of human BACE 2 reacts with mid region on BACE 2 (60-70 kDa) -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, azide, puriafied)
WB Human, Mouse, Rat immunogen = synthetic peptide, corresp. to aa 485-501 of human BACE BACE -
AbD Serotec polyclonal
Goat
(liquid, serum, purified, azide)
IH Human immunogen = synthetic peptide, C L R Q Q H D D F A D D I S L L K, corresp.to the C-terminal aa seq. 458-501 of human BACE BACE, C-terminal -
AbD Serotec polyclonal
IgG
Rabbit
(liquid, Ig, purified, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 44-59, N-terminal of human BACE2 BACE2, N-terminal -
AbD Serotec polyclonal
IgG
Rat
(liquid, Ig, purified, PBS, azide)
IH Human, Mouse, Rat immunogen = synthetic peptide near N-terminal of human BACE1 BACE1 -
Covance Research Products, Inc (now BioLegend) monoclonal
Ig
Guinea Pig
(crude antiserum)
IH, IP, WB Human, Mouse, Rat immunogen = a peptide sequence C L R Q Q H D D F A D D I S L L K , the C-terminal 17 aa of human BACE1 recognises the mature and immature forms of BACE -
Covance Research Products, Inc (now BioLegend) monoclonal
Ig
Rabbit
(crude antiserum)
IH, IP, WB Human, Mouse, Rat immunogen = a peptide sequence C G I R L P L R S G L G G A P L G L R L P R, 22 aa of human proBACE1 proBACE1 -
ProSci polyclonal
IgG
Rabbit
(purified, azide, Store at -20°)
WB Human, Mouse immunogen = aa 485 to 501, (C L R Q Q H D D F A D D I S L L K) of human BACE 70 kDa BACE -
ProSci polyclonal
IgG
Rabbit
(liquid, purified, PBS, azide)
IB Human immunogen = synthetic peptide corr. to aa. 496-511 near the C-terminal of human BACE2 ~75 kDa BACE2 protein -
ProSci polyclonal
IgG
Rabbit
(liquid, purified, azide)
IB Human, Mouse, Rat immunogen = synthetic peptide corr. to aa. 44-59 near the N-terminal of human BACE2 ~75 kDa BACE2 protein -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(liquid, PBS, azide)
IH Human immunogen = synthetic peptide of internal domain of human BACE1, conj. KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(liquid, affinity purified)
IH Human immunogen = synthetic peptide near the N-terminus of human BACE1, conj. KLH BACE 1 -
LifeSpan Biosciences, Inc.
Cat# cat# LS-C377
polyclonal
Rabbit
(liquid, PBS, azide, ion exchange chromatography)
IC, WB Human, Mouse immunogen = synthetic peptide corresp. to 17 aa near the CT of human BACE BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Goat
(unpurified serum)
ELISA, IH Human immunogen = synthetic peptide (C L R Q Q H D D F A D D I S L L K) recognizes the C-terminal aa sequence 485-501 of human beta amyloid cleaving enzyme protein -
LifeSpan Biosciences, Inc. polyclonal
Goat
(unpurified serum)
ELISA, WB Human immunogen = synthetic peptide 17 aa within the cytoplasmic, C-terminal domain of the rat NHE4, conj. KLH BACE1 -
LifeSpan Biosciences, Inc. polyclonal
Goat
(unpurified serum)
ELISA, WB Human immunogen = synthetic peptide 10 aa peptide near the NT of mouse BACE/Asp2 BACE1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
ELISA, IF, IH, WB Mouse immunogen = synthetic peptide corresp. to 10 aa near the NT of mouse BACE/Asp2 conjugated to KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
ELISA, WB Mouse immunogen = synthetic peptide 10 aa peptide near the NT of mouse BACE/Asp2, conj. to KLH BACE/Asp2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
ELISA, WB Human immunogen = synthetic peptide 17 aa peptide near the CT of human BACE/Asp2, conj. to KLH BACE/Asp2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conjugated to KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conjugated to KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conjugated to KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(protein A purified)
WB Human immunogen = solubilized total recombinant protein BACE 1; cross-reactivity with BACE2 is almost negligible -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(unpurified serum)
WB Human immunogen = synthetic peptide corresp. to aa sequence 26-45 of BACE1 BACE 1; proBACE; does not detect mature BACE -
LifeSpan Biosciences, Inc. polyclonal
Goat
(unpurified serum)
IH Human immunogen = synthetic peptide C L R Q Q H D D F A D D I S L L K corresp. to the C-terminal aa458-501 of human BACE recognizes beta amyloid cleaving enzyme (BACE), a 70kD aspartic protease -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
WB Mouse immunogen = synthetic peptide derived from the C-terminal region of the human BACE protein recognizes C-terminal of BACE protein -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
WB Human immunogen = synthetic peptide corresponding to aa 485-501 (C485 L R Q Q H D D) recognizes secretase. (~70kDa) -
LifeSpan Biosciences, Inc. polyclonal
Goat
WB Human - BACE1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(unpurified serum)
WB Human immunogen = synthetic peptide corresp. to aa46-65 (E T D E E P E E P G R R G S F V E M V D) of human BACE1 proBACE and mature BACE -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
ELISA, IF, IH, WB Human immunogen = synthetic peptide of 20 aa near the CT of human BACE2/Asp1, conjugated to KLH BACE/Asp2; no significant sequence homology exists with BACE2/Aps1, a homolog of BACE, or other Asps -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(PBS, azide, affinity purified)
IH, WB Human, Mouse, Rat immunogen = synthetic peptide (A P T P G P G T P A E R H A D G) corresp. to aa 44 to 59 of human BACE2 BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(PBS, azide, affinity purified)
IH, WB Human immunogen = synthetic peptide corresp. to aa near the C- terminus of human BACE2 BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(unpurified serum)
ELISA, WB Human immunogen = 20 aa synthetic peptide near the CT of human BACE2/Asp1 conjugated to KLH BACE2 BACE2/Asp2; no seq. homology exists with BACE2/Aps1 or other Asps -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conj. to KLH BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conj. to KLH BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
ELISA Human immunogen = synthetic peptide conj. to KLH BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
WB Human, Mouse immunogen = synthetic peptide derived from the C-terminal seq. of the human BACE 2 protein C-terminal region of BACE2 protein -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(IgG fract.)
WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 44-59 of human BACE2 BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(DEAE-column chromatography)
WB Human, Mouse immunogen = synthetic peptide derived from the mid-region of human BACE 2 protein mid-region of BACE2 protein -
Chemicon and Upstate are Millipore monoclonal
IgG1
Mouse
(purified, PBS, azide)
IC, IH, IP, WB Primate (various), Human, Mouse, Rat immunogen = synthetic peptide, C-terminus of BACE BACE, not BACE2; recognizes pro and mature forms -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, serum, affinity purified, PBS, azide)
IH, WB Human, Monkey, Mouse, Rat immunogen = synthetic peptide corresponding to C-terminus of human BACE BACE; recognizes a band of ~70-75 kDa. and at ~45 kDa -
Chemicon and Upstate are Millipore polyclonal
Rabbit
(liquid, serum)
IP, WB Human, Mouse, Rat immunogen = synthetic peptide from the C-terminus of human BACE2 BACE2 -
R&D Systems kit
Unknown Host
(extraction buffer, reaction buffer, 96 well microplate)
IF - immunogen = APPpeptide REEVNLDAEFKR using EDANS/DABCYL as the reporter system detects enzymatic activity of the β-secretase class of proteases associated withthe cleavage of APP -
R&D Systems kit
Unknown Host
(extraction buffer, reaction buffer, 96 well microplate)
IF - immunogen = APPpeptide GVVIATVIV using EDANS/DABCYL as the reporter system detects enzymatic activity of the γ-secretase class of proteases associated withthe cleavage of APP -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, azide, affinity purified)
IH Human, Mouse, Rat immunogen = synthetic peptide from the N- terminus of human BACE1, conjugated to KLH BACE -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, IgG fraction, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, C-terminal residues C(485) L R Q Q H D D F A D D I S L L K(501) β-secretase 1 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(affinity purified PBS, azide)
WB Human immunogen = synthetic peptide, C Q R R P R D P E V V N D E S S (aa. 496-511) of human β-secretase 2 ~75 kDa β-secretase 2 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, purified, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, A P T P G P G T P A E R H A D G (aa 44-59) of human β-secretase 2 β-secretase 2 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(epitope affinity purified, PBS, BSA, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, V S E I S G P F S T E D I A S N C (aa. 441-457) of human β-secretase 2 human β-secretase 2 from transfected cells. -
A D I polyclonal
Rabbit
(liquid, serum or affinity purified)
ELISA, WB Mouse, Rat immunogen = a 17 aa peptide, designated BACE11-P control peptides, near the CT of human BACE/Asp2, KLH conj. BACE/Asp2 only, not BACE2/Asp1 -
A D I polyclonal
Rabbit
(serum, agarose purified or affinity purified)
ELISA, WB Human immunogen = a 20 aa peptide, designated BACE21-P control peptides, near the CT of human BACE2/Asp1, KLH conj. BACE2/Asp1 -
A D I monoclonal

(Peptide Substrate, Store at -20°)
- - immunogen = 14 aa peptide of human APP 590-603Acetyl-EISEVNL  DA EFR D-amide   -
A D I monoclonal

(Peptide Substrate, Store at -20°)
- - immunogen = 14 aa peptide of human APP 590-603 Acetyl-E I S E V K M D A E F R D-amide   -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, serum, no preserve)
IP, WB Human, Hamster immunogen = synthetic peptide, C-R Q Q H D D F A D D I S L L K, corresp. to aa 487-501 of human BACE recognizes the ~65 and ~75 kDa glycosylated forms of BACE protein -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, azide)
WB Human immunogen = synthetic peptide corresp. to aa. 496-511 of human BACE2 ~75 kDa BACE2 protein; cross-reacts with 52 kDa and 39 kDa unknown protein -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 44-59 of human BACE2 ~75 kDa BACE2 protein -
Chemicon and Upstate are Millipore polyclonal
IgG
Goat
(serum, thimerosal)
ELISA, IH, WB Human immunogen = synthetic peptide corresponding to aa 485-501 of BACE 70 kDa glycosylated form of BACE. -
Exalpha Biologicals polyclonal
IgG
Rabbit
(purified, PBS, azide)
WB Human, Mouse synthetic peptide, aa485-501 of human BACE, C-terminal 70 kDa BACE -
Exalpha Biologicals polyclonal
IgG
Rabbit
(purified, PBS, azide)
WB Human, Mouse, Rat synthetic peptide, aa44-59 of human BACE2, N-terminal 70 kDa BACE2 -
Exalpha Biologicals polyclonal
IgG
Rabbit
(purified, PBS, azide)
WB Human, Mouse, Rat synthetic peptide, aa496-511 of human BACE2, C- terminal 70 kDa BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(liquid, PBS, azide, affinity purified)
IH Human immunogen = synthetic peptide near the N-terminus of human BACE1, conj. KLH BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
IgG
Rabbit
(liquid, PBS)
IH Human immunogen = synthetic peptide near the N-terminal of human BACE1 BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
WB - - BACE 1 -
LifeSpan Biosciences, Inc. polyclonal
IgG
Rabbit
(liquid, PBS)
WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 44-59 of human BACE2 (N-terminal) BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
WB Human, Mouse, Rat - BACE2 -
LifeSpan Biosciences, Inc. polyclonal
IgG
Sheep
(lyophilized, PBS, affinity purified)
ELISA, IP, WB Human immunogen = NS0-derived rhBACE-2 (aa63-466) BACE2 -
LifeSpan Biosciences, Inc. polyclonal
Rabbit
(liquid, PBS, azide, purified)
IH, WB Human, Mouse, Rat immunogen = synthetic peptide corresp. to aa 44-59 of human BACE2 BACE2 -
Novus Biologicals polyclonal
IgG
Rabbit
(liquid, affinity purified, BSA, PBS, azide)
WB Human immunogen = synthetic peptide, C L R Q Q H D D F A D D I S L L K, aa 458-501 of human BACE Transfected BACE1 -
Novus Biologicals polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human, Mouse, Rat immunogen = synthetic peptide, V S E I S G P F S T E D I A S N C, aa441-457 of human BACE2 BACE2 -
Novus Biologicals polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human immunogen = synthetic peptide, C P E V V N D E S S LV R H R W K, aa 503-518 of human BACE2 BACE2 -
Novus Biologicals polyclonal
IgG
Rabbit
(liquid antisera, PBS, azide, purified)
WB Human, Mouse, Rat immunogen = Synthetic peptide, corresp. to aa. 485-501 of Human BACE; peptide sequence differs from those of mouse and rat BACE by one amino acid detects the 70 kD band of BACE -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
ELISA, IP, WB Human, Mouse immunogen = synthetic peptide, C L R Q Q H D D F A D D I S L L K, aa485-501 of human β-secretase 1 transfected β-secretase 1 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(affinity purified, azide)
IF, WB Human immunogen = synthetic peptide, aa. 122-131 of human β-secretase 1 β-secretase 1 -
A B R - Thermo Scientific monoclonal
IgG
Mouse
(liquid)
ELISA, IH, WB Human immunogen = beta-Secretase 1 (aa 22~502) full length recombinant protein with GST tag β-secretase 1 -
A B R - Thermo Scientific polyclonal
IgG
Goat
(liquid, whole antiserum, azide)
IH Human immunogen = synthetic peptide, corresp. to C-terminal residues C L R Q Q H D D F A D D I S L L K(aa 485-501) of the human β-secretase 1 protein β-secretase 1 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human, Mouse immunogen = synthetic peptide, C-P E V V N D E S S L V R H R W K (aa 503-518) of human β-secretase 2 human β-secretase 2 from transfected cells. -
R&D Systems monoclonal
IgG1
Mouse
(IgG fract, protein-G, PBS, trehalose, lyophilized)
ELISA, IP, Neut, WB Human immunogen = purified, NS0-derived recombinant human BACE-1 ectodomain (aa 22-460) rhBACE-1, ectodomain -
R&D Systems polyclonal
Goat
(affinity purified, PBS, lyophilized)
ELISA, WB Human immunogen = purified, NS0-derived recombinant human BACE-1 ectodomain rhBACE-1 -
R&D Systems polyclonal
IgG
Goat
(affinity purified, Biotin, PBS, lyophilized)
WB Human immunogen = purified, NS0-derived recombinant human BACE-1 ectodomain BACE-1 -
R&D Systems monoclonal
IgG1
Mouse
(IgG fract, protein-G, PBS, trehalose, lyophilized)
ELISA, FC, IC, WB Human immunogen = purified, NS0-derived recombinant human BACE-1 ectodomain (aa 22-460) rhBACE-1 -