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Antibodies

854 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
γ-secretase/ Presenilins From labs (7)
antibodies 95/23 and 98/1(Janetta Culvenor,Department of Pathology, The University of Melbourne, Victoria, Australia)used in paper by Runz, 2002 polyclonal
Rabbit
WB - epitope at PS1, aa 1-20 PS1 in human neuroblastoma SH-SY5Y wild type and PS1 transfectants (SY5Y-PS1) as well as in mouse P19, in CHO-K1 and CHO-APP770 transfected cells, in rat cerebellar granule and hippocampal neurons, and astrocytes. 50 kDa and 30 kDa presumptive cleavage product in WB -
anti-PS1 CTF29414(C. Elle,Center for Molecular Biology Heidelberg (ZMBH), University of Heidelberg, INF 282, D-69120 Heidelberg)used in paper by Runz, 2002 polyclonal

- -     -
PS1-3027(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002 polyclonal

- - loop domain (aa 263-407) of PS-1 loop domain of PS-1 -
PS1-2953(Christian Haass,Adolf Butenandt Institute, University of Munich) polyclonal

- - N-terminus (aa 2-81) of PS-1 N terminus of PS-1 -
PS2-3711(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002 polyclonal

- - loop domain (aa 297-356) of PS-2 loop domain of PS-2 -
PS2-2972(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002paper by Esler, 2002 polyclonal

- - N terminus of PS-2 N terminus of PS-2 -
PS1-BIH.F5C(Christian Haass,Adolf Butenandt Institute, University of Munich)used in paper by Steiner, 2002 monoclonal

- - fusion protein, C-terminal (aa 297-356) C terminus of PS-2 -
γ-secretase/ Presenilins From manufacturers (93)
Accurate polyclonal
Goat
- - immunogen = 14-33 aa of N-Terminus, extracellular region S182 peptide -
Accurate polyclonal
Goat
IH, ELISA Human   Presenilin 2 -
Biodesign Meridian LifeScience polyclonal
Goat
(neat, liquid, azide)
IH, WB, ELISA Human immunogen = synthetic peptide, 14-33 aa of N-Terminus aa 14-33 of Presenilin-1 -
Biodesign Meridian LifeScience polyclonal
Goat
(neat, liquid, azide)
IH, WB, ELISA Human immunogen = synthetic peptide, 31-47 aa of N-Terminus aa 31-47 of Presenilin-2 -
R&D Systems polyclonal
IgG
Goat
(affinity purified, PBS, filtered, lyophilized)
IH, WB, ELISA Human immunogen = purified E.Coli-derived recombinant human PS-2 NTF (aa 1-80) hPS-2 NTF; < 1% cross with rhPS-1 NTF (aa 1-80) and rhPS-2 CTF (aa 308-388) -
R&D Systems polyclonal
IgG
Goat
(affinity purified, Biotin, PBS, filtered, lyophilized)
WB Human immunogen = purified E.Coli-derived recombinant human PS-1 NTF (aa 1-80) hPS-1 NTF; in WB < 1% cross with rhPS-1 CTF (aa 298-407) and rhPS-2 NTF (aa 1-80) -
Biotrend polyclonal
Goat
(liquid, Ig fract, PBS, azide)
IH, ELISA - immunogen = synthetic peptide corr. to aa 14 - 33 of N-Terminus Presenilin-1 N-terminal residues 14-33 -
R&D Systems polyclonal
IgG
Goat
(affinity purified, Biotin, PBS, filtered, lyophilized)
IH, WB Human immunogen = purified E.Coli-derived recombinant human PS-1 CTF (aa 298-407) hPS-1 CTF; < 1% cross with rhPS-1 NTF (aa 1-80) and rhPS-2 CTF (aa 322-388) in WB -
R&D Systems polyclonal
IgG
Goat
(affinity purified, PBS, filtered, lyophilized)
IH, WB, ELISA Human immunogen = purified E.Coli-derived recombinant human PS-1 NTF (aa 1-80) rhPS-1 NTF; no cross with rhPS-1 CTF (aa 298-407) or rhPS-2 NTF (aa 1-80) -
R&D Systems polyclonal
IgG
Goat
(affinity purified, PBS, filtered, lyophilized)
IH, WB, ELISA Human immunogen = purified E.Coli-derived recombinant human PS-2 CTF (aa 322-388) rhPS-2 CTF; < 1% cross with rhPS-1 NTF (aa 1-80), rhPS-1 CTF (aa 298-407) or rhPS-2 NTF (aa 1-80) -
AbD Serotec polyclonal
Goat
(liquid, serum, azide)
IH Human immunogen = synthetic peptide corr. to aa 31-47 of Presenilin-2 recognizes Presenilin-2, binding to neurons in both normal and Alzheimer disease brain -
A B R - Thermo Scientific polyclonal
IgY
Chicken
(purified, PBS, BSA, azide)
WB Human, Mouse, Rat immunogen = synthetic peptides, (aa 311-322) and (aa 342-353) PS-1 -
A B R - Thermo Scientific monoclonal
IgG1
Mouse
(protein-G, PBS, BSA, azide)
IF, IH, WB, ELISA Human, Mouse, Rat, Primate (various) immunogen = synthetic peptide, N-terminal (aa 21-34) PS-1; no cross with PS-2 -
A B R - Thermo Scientific monoclonal
IgG1
Mouse
(protein-G, PBS, BSA, azide)
IF, WB, ELISA Human, Mouse, Rat, Primate (various) immunogen = synthetic peptide, C-terminal (aa 313-334) PS-1; no cross with PS-2 -
A B R - Thermo Scientific monoclonal
IgG1
Mouse
(protein-G, PBS, BSA, azide)
IF, WB, ELISA Human, Rat, Primate (various) immunogen = synthetic peptide, (aa 31-45) PS-2; no cross with PS-1 -
A B R - Thermo Scientific monoclonal
IgG1
Mouse
(protein-G, PBS, BSA, azide)
IF, WB, ELISA Human, Mouse, Rat, Primate (various) immunogen = synthetic peptide, C terminal (aa 317-334) PS-2; no cross with PS-1 -
A B R - Thermo Scientific polyclonal
IgG
Rabbit
(IgG, epitope affinity purified IgG, PBS, BSA, azide)
WB Hamster immunogen = synthetic peptide corresponds to aa 2-18 of mouse ubiquilin Ubiquilin from hamster cells -
Cell Signaling polyclonal
Rabbit
(affinity purified)
WB Human, Monkey, Mouse, Rat immunogen = synthetic peptide corr. to C-terminus of human Nicastrin, conj. to KLH endogenous levels of Nicastrin -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified)
IC, IF, IP, WB Human, Mouse immunogen = synthetic peptide, conj. to KLH, corr. to N-terminal aa 103-124 of nicastrin ~85 kDa nicastrin -
Biodesign Meridian LifeScience polyclonal
IgG
Rabbit
(liquid, protein-A purified, PBS, no preservative)
IP, WB Human immunogen = synthetic peptide corr. to aa residues 689-709 at C-terminus of nicastrin reacts with nicastrin protein -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping within an internal region of APH-1 of human origin. 18 kDa Aph-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB C. elegans immunogen = peptide mapping within an internal region of APH-1 of C.Elegans origin. Aph-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB C. elegans immunogen = peptide mapping at the C-terminus of APH-1 of C.Elegans origin. Aph-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, IP, WB Human, Mouse, Rat immunogen = peptide mapping near the N-terminus of Nicastrin of human origin. 120 and 145 kDa Nicastrin -
Autogen Bioclear polyclonal
IgG
Rabbit
(liquid, PBS, azide, gelatin, affinity purified)
IF, IP, WB Human, Mouse, Rat immunogen = epitope corresp. to aa 1-300 at the N-terminus of Nicastrin of human origin. 120 and 145 kDa Nicastrin -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping at the N-terminus of PEN-2 of human origin. PEN-2 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PEN-2 of human origin. PEN-2 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, C. elegans immunogen = peptide mapping within an internal region of PEN-2 of C. elegans origin. PEN-2 -
Autogen Bioclear polyclonal
IgG
Rabbit
(liquid, PBS, azide, gelatin, affinity purified)
IF, IP, WB Human, Mouse, Rat immunogen = peptide mapping corresp. aa to 1-101, representing full length PEN-2 of human origin. PEN-2 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping near the C-terminus of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Mouse, Rat immunogen = peptide mapping within an internal region of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping near the C-terminus of PLIC-2 of human origin. Ubiquilin2/PLIC-2 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PLIC-2 of human origin. Ubiquilin2/PLIC-2 -
Autogen Bioclear polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Mouse, Rat immunogen = peptide mapping within an internal region of PLIC-2 of mouse origin. Ubiquilin2/PLIC-2 -
Bachem kit
Rabbit
IF - Immunogen = aa 1-17 of human nicastrin - -
Bachem polyclonal
Rabbit
(purified antiserum)
- - Immunogen = aa 1-17 of human nicastrin - -
Bachem polyclonal
Rabbit
(diluted antiserum)
RIA - Immunogen = aa 1-17 of human nicastrin - -
Bachem polyclonal
Rabbit
(undiluted antiserum)
IH - Immunogen = aa 1-17 of human nicastrin - -
Bachem kit
Rabbit
RIA - Immunogen = aa 1-17 of human nicastrin - -
Bachem kit
Rabbit
(high sensitivity)
ELISA - Immunogen = aa 656-676 of human nicastrin - -
Bachem kit
Rabbit
(high sensitivity)
ELISA - Immunogen = aa 1-17 of human nicastrin - -
Bachem kit
Rabbit
IF - Immunogen = aa 656-676 of human nicastrin - -
Bachem kit
Rabbit
RIA - Immunogen = aa 656-676 of human nicastrin - -
Bachem kit
IgG
Rabbit
(purified antiserum)
- - Immunogen = aa 656-676 of human nicastrin - -
Bachem polyclonal
Rabbit
(undiluted antiserum)
IH - Immunogen = aa 656-676 of human nicastrin - -
Bachem polyclonal
Rabbit
(diluted antiserum)
RIA - Immunogen = aa 656-676 of human nicastrin - -
Immunologicals Direct AbD Serotec polyclonal
IgG
Rabbit
(liquid, purified, PBS, no carrier, no preservative)
IP, WB Human immunogen = aa 698-709 of nicastrin nicastrin protein -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, undiluted serum, conj. with KLH)
IB, IP, RIA Human, Mouse immunogen = synthetic peptide corr. to aa residues 689-709 at C-terminus of nicastrin both the latent and active forms of Nicastrin -
Covance Research Products, Inc (now BioLegend) polyclonal
IgG
Rabbit
(liquid, purified, PBS, no carrier, no preservative)
IP, WB Human immunogen = aa 698-709 of nicastrin nicastrin protein -
Calbiochem EMD Biosciences polyclonal
IgG
Rabbit
(liquid, undiluted serum, conj. with KLH)
IB, IF, IP Human, Mouse immunogen = synthetic peptide corr. to aa residues 62-93 at N-terminus of nicastrin both the letent and active forms of Nicastrin -
Insight Biotechnology polyclonal
IgG
Rabbit
(liquid, PBS, azide, gelatin, affinity purified)
IF, IP, WB Human, Mouse, Rat immunogen = epitope corresp. to aa 1-300 at the N-terminus of Nicastrin of human origin. 120 and 145 kDa Nicastrin -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping within an internal region of APH-1 of human origin. 18 kDa Aph-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB C. elegans immunogen = peptide mapping within an internal region of APH-1 of C.Elegans origin. Aph-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB C. elegans immunogen = peptide mapping at the C-terminus of APH-1 of C.Elegans origin. Aph-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, IP, WB Human, Mouse, Rat immunogen = peptide mapping near the N-terminus of Nicastrin of human origin. 120 and 145 kDa Nicastrin -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PEN-2 of human origin. PEN-2 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, C. elegans immunogen = peptide mapping within an internal region of PEN-2 of C. elegans origin. PEN-2 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping near the C-terminus of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Mouse, Rat immunogen = peptide mapping within an internal region of PLIC-1 of human origin. Ubiquilin1/PLIC-1 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human, Mouse, Rat immunogen = peptide mapping near the C-terminus of PLIC-2 of human origin. Ubiquilin2/PLIC-2 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Human immunogen = peptide mapping within an internal region of PLIC-2 of human origin. Ubiquilin2/PLIC-2 -
Insight Biotechnology polyclonal
IgG
Goat
(liquid, PBS, azide, gelatin, affinity purified)
IF, WB Mouse, Rat immunogen = peptide mapping within an internal region of PLIC-2 of mouse origin. Ubiquilin2/PLIC-2 -
Interchim polyclonal
Rabbit
(antiserum)
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Interchim polyclonal
Rabbit
- - - - -
Accurate polyclonal
Goat
- Human   Presenilin 2 -
Accurate polyclonal
Goat
(serum)
ELISA, IH Human   Presenilin 2 -
A D I monoclonal
Rat
(antiserum, ascites, unpurified)
ELISA, IF, IH, IP, WB Human, Mouse, Rat immunogen = GST-human PS1 fusion protein (aa 21-80) Presenilin-1 -
Acris Antibodies monoclonal
Rat
(antiserum, ascites, unpurified)
ELISA, IF, IH, IP, WB Human, Mouse, Rat immunogen = GST-human PS1 fusion protein (aa 21-80) Presenilin-1 -
Acris Antibodies polyclonal
Rabbit
(unpurified antiserum)
ELISA, IF, IH, IP, WB Human, Mouse, Rat, Xenopus immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1 Presenilin-1 -
Acris Antibodies polyclonal
IgG
Rabbit
(affinity purified with PBS, BSA and merthiolate)
ELISA, IF, IH, IP, WB Human, Mouse, Rat, Xenopus immunogen = a 15 mer peptide (PS11-P) locating to the large hydrophilic loop of human or mouse Presenilin-1 Presenilin-1 -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, azide, affinity purified)
WB Human, Mouse immunogen = synthetic peptide derived from within residues 1-100 of human PEN2, conj. to KLH PEN2 (12kDa); higher mwt bands also detected at ~50 and 100kDa due to portion of Pen2 bound to components of gamma secretase complex -
Abcam polyclonal
IgG
Rabbit
(liquid, whole serum)
IP, WB Human immunogen = synthetic peptide (F Q I Y R P R W G A L G D Y L S F T I P L G T P) of human PEN2 Pen-2 protein -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Hamster, Mouse immunogen = synthetic peptide, A E S A E S G G P P G A Q D S A A, corr. to aa 2-18 of mouse ubiquilin ~63 kDa ubiquilin -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, glycerol, BSA, azide, affinity purified)
IF, WB Human immunogen = synthetic peptide from loop region of human Aph-1b; Epitope seq. C K L L K K A S E G L K S I N P G E T A P S M R Aph 1b -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, BSA, glycerol, azide, affinity purified)
IF, WB Human immunogen = synthetic peptide containing the C- terminal seq. of human Aph 1b; Epitope seq. C Q D K N F L L Y N Q R S R Q D K N F L L Y N Q R S R Aph-1b -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, BSA, azide, affinity purified)
WB Human, Mouse, Rat immunogen = synthetic peptide derived from residues 50-150 of human APH1a recognises both isoforms of APH1a (encoded on chromosome 1) -
Abcam polyclonal
IgG
Rabbit
(liquid, PBS, glycerol, PBS, azide, affinity purified)
IF, IP, WB Human, Mouse immunogen = synthetic peptide (C R R Q E D S R V M V Y S A L R I P P E D corresp. to C-terminal domain of the long isoform of aa 245-265 of human APH1a, conj. to KLH Anterior Pharynx Defective 1 (APH1a) -
Abcam polyclonal
IgG
Rabbit
(liquid, affinity purified, PBS, BSA, azide)
WB Human, Mouse immunogen = synthetic peptide (I N A K A D V L F I A P R E P G A V S Y corr. to C-terminal aa 688-708 from human nicastrin ~110 kDa nicastrin -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protein G purified)
ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 110 aa of human APH1, conj. to KLH Aph1 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protein G purified)
ELISA Human immunogen synthetic peptide, 10-30 aa, at the C-term of last 50 aa of human APH1 Aph1 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protien G purified)
ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 50 aa of human PEN2, conj. to KLH Pen2 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protein G purified)
ELISA Human immunogen = synthetic peptide, 10-30 aa, at the N-term of first 60 aa of human PEN2 Pen2 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protein G purified)
ELISA Human immunogen = synthetic peptide (10-30 aa) at the N-term of first 100 aa of human PEN2, conj. to KLH Pen2 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide)
ELISA Human immunogen = synthetic peptide selected from the N-terminal region of human PEN2, conj. to KLH Pen2 -
ABGENT polyclonal
Rabbit
(liquid, Ig fraction, PBS, azide)
ELISA Human immunogen = synthetic peptide selected from the center region of human PEN2, conj. to KLH Pen2 -
ABGENT polyclonal
Rabbit
(liquid, PBS, azide, protein G purified)
ELISA, WB Human, Mouse immunogen = synthetic peptide (10-30 aa in length) at the N-term of first 100 aa of human Ubiquilin1, conj. to KLH ubiquilin1 -