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Antibodies

16 Results

Name Source Clonality &
Isotype
Host &
Formulation
Method Reactivity Immunogen/
Epitope
Specificity Availability
Prion protein From labs (5)
P45-66Reference: Dossena, 2008(provided by David Harris, Washington Universityin St. Louis) polyclonal
IgM
Rabbit
EMSA, IP, WB Mouse raised against synthetic peptide-encompassing mouse PrP (MoPrP) residues 45 to 66 recognizes PrP -
Reference: Dossena, 2008(provided by Jan PM Langeveld, CIDC-Lelystad, the Netherlands) monoclonal
Mouse
IH, WB Bovine, Ovine immunogen = bovine PrP aa 97-115, corresp to ovine PrP sequence 89–107, conj to KLH at C-terminus. (epitope at 93WGQGG97) recognizes PrP, PK-cleavage sitespecific -
SA65Reference: Dossena, 2008(provided by Gianluigi Zanusso, Department of Neurological and Visual Sciences, University of Verona) monoclonal
Mouse
EM, IH, WB Bovine, Ovine, Human, Mouse, Rat immunogen = recombinant human PrP23–231; epitope in alpha-helix 1 of PrP recognizes all glycoforms of PrP -
Reference: Dossena, 2008(provided by Alex Raeber and Bruno Oesch, Prionics, Zurich) monoclonal
IgM
Mouse
IP, WB Bovine, Human, Mouse (three polypeptide segments responsible for the 15B3 epitope: 15b3-1 involves residues 142-148 GSDYEDR(YY); 15b3-2 residues 162-170 YYRPVDQYS;15b3-3 residues 214-226 CITQYQ RESQAYY) recognizes both protease resistant and protease sensitive forms of abnormal, disease associated PrP -
6D11(R.J. Kascsak, Department of Neurology, New York University School of Medicine, New York, NYPaper, DS Spinner, 2007) Reference: E Chung, 2010 monoclonal
IgG2a
Mouse
(liquid, tissue-culture supernatant or ascites, purified)
ELISA, IH, WB Bovine, Elk, Ovine, Mule deer, Human, Hamster, Mouse Prnp-/- mice were immunized with nondenatured 139A scrapie-associated fibrils (SAF) and with ODN 1826 reacts with the N-terminal epitope residues 97-100, QWNK, in native and denatured forms of PrPSc and recombinant PrP -
Prion protein From manufacturers (11)
Signet Covance monoclonal
IgG1
Mouse
(supernatant, purified, PBS, no preservatives or carrier proteins)
ELISA, IF, IH, WB Cat, Rabbit, Sheep The epitope site appears to be non-linear (discontinuous). This antibody recognizes both the cellular (protease sensitive) and infectious (protease resistant) isoforms of PrP -
Signet Covance monoclonal
IgG1
Mouse
(supernatant, purified, PBS, no preservatives or carrier proteins)
ELISA, IH, WB Bovine, Sheep, Mouse Immunogin within recombinant mouse PrP protein, aa 23-237 7D9 reacts exceptionally well with bovine, sheep, and mouse PrP. It is 10 fold less reactive to feline, hamster, and human PrP. 7D9 recognizes both protease sensitive and protease resistant forms of PrP -
Cayman Chemical monoclonal
IgG2b
Mouse
(lyophilized IgG)
ELISA, FC, IH, WB Bovine, Ovine, Human, Hamster, Mouse immunogen = a preparation of SAF (scrapie associated fibrils) from infected hamster brain recognizes the octo-repeat region located in the N-terminal region of PrP -
- monoclonal
IgG1
Mouse
(liquid, serum-free medium, azide)
ELISA, IH, WB Mammal (various), Human The epitope falls within amino acids 144-152, (DYEDRYYRE) of human prion protein mAB 6H4 recognizes the sequence DYEDRYYRE in the prion protein; reacts on Western blots with mouse andhamster PrP, indicating that the substitution at position 145 does not prevent binding of 6H4 -
- monoclonal
IgG2b
Mouse
(liquid, culture supernatant; serum-free medium, azide)
WB Bovine, Deer, Rabbit, Pig epitope within position138-142 with numbering according to the human PrP mAB 34C9 recognizes the sequence LIHFG in the bovine prion protein. This sequence is conserved in bovine,rabbit, pig, and mule deer PrP sequences but not in human, mouse or hamster PrP -
Signet Covance monoclonal
IgG2A
Mouse
(liquid, ascites,)
ELISA, IH, IP, WB Cat, Human, Hamster epitope lies within amino acids 109-112 of prion protein 3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing) -
Signet Covance monoclonal
IgG2A
Mouse
(liquid, purified, PBS, biotin conj.)
ELISA, IH, IP, WB Cat, Human, Hamster epitope lies within amino acids 109-112 of prion protein 3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing) -
Novus Biologicals polyclonal
IgG
Goat
(affinity purified antisera, Tris-saline, BSA, azide)
ELISA, WB Human immunogen = synthetic peptide, C-SDYEDRYYREN, representing the internal region of the human protein specific for the prion protein; 25kDa band in WB -
Novus Biologicals monoclonal
IgG
Rabbit
(ascites, Tris-glycine, saline, glycerol, BSA, azide)
FC, IC, IH, WB Human, Mouse, Rat immunogen = synthetic peptide corresponding to residues near the C-terminus of human Prp Specific for PrP -
Signet Covance monoclonal
IgG2A
Mouse
(liquid, purified, PBS,)
ELISA, IH, IP, WB Cat, Human, Hamster epitope lies within amino acids 109-112 of prion protein 3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing) -
Signet Covance monoclonal
IgG2A
Mouse
(liquid, affinity purified, PBS, no preservatives or carrier proteins)
ELISA, IB, IH Bovine, Deer, Elk, Mule, Sheep, Human, Hamster, Mouse The epitope falls within amino acids 93-109 of PrP 6D11 reacts with both the PrPc and PrPsc forms -