Antibody

PS-2

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Clonality: polyclonal
Host: Rabbit
Methods: IH, WB
Source: PS2 (GL2)
(Takeshi Iwatsubo, Department of Neuropathology & Neuroscience, Grad. School of Pharmaceutical Sciences, University of Tokyo)
References:
Zhao, 2010
Yu, 2001
Reactivity:
Reacts in: Human
reference <a href="http://www.jbc.org/content/273/33/21153.full" target="_new">paper</a>: Tomita T, Tokuhiro S, Hashimoto T, Aiba K, Saido T C, Maruyama K, Iwatsubo T. J. Biol. Chem 273, 21153-21160, 1998

Immunogen/Epitope

immunogen = GST fused to amino acids 301–361 of human PS2

Specificity

detects C-terminus of PS-2

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References

Paper Citations

  1. . Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci. 2010 Feb 3;30(5):1648-56. PubMed.
  2. . APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. Neuron. 2001 Sep 13;31(5) PubMed.

External Citations

  1. Takeshi Iwatsubo
  2. paper

Further Reading

No Available Further Reading