Antibody

PrPSc and recPrP (6D11)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG2a
Methods: ELISA, IH, WB
Source: 6D11
(R.J. Kascsak, Department of Neurology, New York University School of Medicine, New York, NY
Paper, DS Spinner, 2007)
Reference:
E Chung, 2010
Formulation: liquid, tissue-culture supernatant or ascites, purified
Reactivity:
Reacts in: Bovine, Elk, Ovine, Mule deer, Human, Hamster, Mouse

Immunogen/Epitope

Prnp-/- mice were immunized with nondenatured 139A scrapie-associated fibrils (SAF) and with ODN 1826

Specificity

reacts with the N-terminal epitope residues 97-100, QWNK, in native and denatured forms of PrPSc and recombinant PrP

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References

Paper Citations

  1. . Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. BMC Neurosci. 2010;11:130. PubMed.

External Citations

  1. DS Spinner, 2007

Further Reading

No Available Further Reading