Antibody

Progranulin

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Clonality: polyclonal
Host: Goat
Isotype: IgG
Source: R&D Systems
Cat# AF2420
Reference:
Rademakers, 2008
Formulation: affinity purified, filtered, PBS, trehalose, lyophilized
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = purified, NS0-derived, recomb. human Progranulin (rhProgranulin)

Specificity

recognizes human progranulin. In direct ELISAs and WB, 30% cross-reactivity with rmProgranulin

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References

Paper Citations

  1. Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, Wszolek ZK, Uitti RJ, Feldman H, Hutton ML, Mackenzie IR, Graff-Radford NR, Dickson DW. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Hum Mol Genet. 2008 Dec 1;17(23):3631-42. PubMed.

Further Reading

No Available Further Reading