Antibody

prion protein (3F4)

Tools

Back to the Top

Clonality: monoclonal
Host: Mouse
Isotype: IgG2A
Methods: ELISA, IH, IP, WB
Source: Signet Covance
Cat# SIG-39620
References:
Gijselinck, 2010
Parkin, 2007
Formulation: liquid, purified, PBS,
Reactivity:
Reacts in: Cat, Human, Hamster
paper, <a href="http://jvi.asm.org/cgi/reprint/61/12/3688" target="_new">Kascsak, et al., 1987</a>

Immunogen/Epitope

epitope lies within amino acids 109-112 of prion protein

Specificity

3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing)

Comments / Questions

Make a comment or submit a question

To make a comment you must login or register.

Comments on this content

No Available Comments

References

Paper Citations

  1. . Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2010 May;67(5):606-16. PubMed.
  2. . Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. PubMed.

External Citations

  1. Kascsak, et al., 1987

Further Reading

No Available Further Reading