prion protein (3F4)

Clonality: monoclonal
Host: Mouse
Isotype: IgG2A
Methods: ELISA, IH, IP, WB
Source: Signet Covance
Cat# SIG-39620
Gijselinck, 2010
Parkin, 2007
Formulation: liquid, purified, PBS,
Reacts in: Cat, Human, Hamster
paper, <a href="" target="_new">Kascsak, et al., 1987</a>


epitope lies within amino acids 109-112 of prion protein


3F4 is reactive to amino acid residues 109-112 of prion protein (PrP) from humans, hamsters, and felines. It recognizes both protease sensitive and protease resistant forms of PrP (after denaturing)

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Paper Citations

  1. . Identification of 2 Loci at chromosomes 9 and 14 in a multiplex family with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Arch Neurol. 2010 May;67(5):606-16. PubMed.
  2. . Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7. PubMed.

External Citations

  1. Kascsak, et al., 1987

Further Reading

No Available Further Reading