Antibody

Nicastrin

Tools

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Clonality: polyclonal
Host: Rabbit
Methods: WB
Source: Sigma Aldrich
Cat# N1660
References:
Zhao, 2010
Osawa, 2008
Sato, 2007
Steiner, 2002
Formulation: buffered aqueous solution , IgG fract, PBS, azide
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = synthetic peptide corr to C-terminus, aa 693-709 of human nicastrin, conj. to KLH

Specificity

detects Nicastrin

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References

Paper Citations

  1. . Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci. 2010 Feb 3;30(5):1648-56. PubMed.
  2. . Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. J Biol Chem. 2008 Jul 11;283(28):19283-92. PubMed.
  3. . Active gamma-secretase complexes contain only one of each component. J Biol Chem. 2007 Nov 23;282(47):33985-93. PubMed.
  4. . PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem. 2002 Oct 18;277(42):39062-5. PubMed.

Further Reading

No Available Further Reading