Antibody

Neurofilament, Pan-Axonal (SMI-312)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1 cocktail
Methods: ELISA, IC, IH, WB
Source: SMI™ COVANCE
Cat# SMI312R
reference
Meyer-Luehmann, 2008
Van Uden, 2002
Zhao, 2006
Formulation: liquid, ascites, concentrate
Reactivity:
Reacts in: Mammal (various)

Immunogen/Epitope

 

Specificity

visualizes axons in an area-specific maturation patternin human fetal brain; visualizes aberrantly sprouting axons in neuriticplaques derived from cortico-cortical fibers in A.D. and identifies loss of synaptic circuitry

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References

Paper Citations

  1. . Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008 Feb 7;451(7179):720-4. PubMed.
  2. . Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. J Neurosci. 2002 Nov 1;22(21):9298-304. PubMed.
  3. . Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci. 2006 Feb;9(2):234-42. PubMed.

Further Reading

No Available Further Reading