Antibody

Insulin Receptor β, phos Tyr1345 (14A4)

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Clonality: monoclonal
Host: Rabbit
Isotype: IgG
Source: Cell Signaling
Cat# 3026
Reference:
Townsend, 2007
Formulation: liquid, HEPES, saline, BSA, glycerol
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = synthetic phospho peptide (KLH-coupled) corresp. to residues surrounding Tyr1345 of human insulin receptor β

Specificity

detects transfected levels of insulin receptor β only when phosphor. at Tyr1345. The antibody slightly cross-reacts with activated IGF-I receptors and some other activated tyrosine kinases

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References

Paper Citations

  1. Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biol Chem. 2007 Nov 16;282(46):33305-12. PubMed.

Further Reading

No Available Further Reading