Antibody

htt

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Clonality: polyclonal
Host: Rabbit
Methods: ELISA
Source: HD 1-17
(Vivian Hook
Departments of Medicine and Neuroscience, UC San Diego)
used in paper by Khoshman, 2002
Formulation: serum
Reactivity:
reference: Mende-Mueller LM, Toneff T ... Hook VY, <em>J. Neurosci</em>. 21, 1830-1837, 2001

Immunogen/Epitope

imunogen = the fist 17 amino acids of htt, the peptide MATLEKLMK AFESLKSFC, with addition of C-term Cys residue for conj. to KLH

Specificity

seems to be especially good for human HD tissue --Ethan Signer, High Q Foundation

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References

Paper Citations

  1. . Effects of intracellular expression of anti-huntingtin antibodies of various specificities on mutant huntingtin aggregation and toxicity. Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):1002-7. PubMed.

Other Citations

  1. Vivian Hook

Further Reading

No Available Further Reading