Antibody

FMRP (1C3)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Source: Chemicon and Upstate are Millipore
Cat# MAB2160
Reference:
Giorgi, 2007
Zalfa, 2007
Hayashi, 2007
Formulation: liquid, ascites, no preservative
Reactivity:
Reacts in: Zebra fish, Human, Monkey, Mouse, Rat

Immunogen/Epitope

immunogen = fusion protein with a full length human FMRP (epitope is localized in the N-terminal half )

Specificity

detects FMRP. Cross reaction with FXR protein may be detected in cases of high expression of the latter proteins

Note

not FC or IP

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References

Paper Citations

  1. Giorgi C, Yeo GW, Stone ME, Katz DB, Burge C, Turrigiano G, Moore MJ. The EJC factor eIF4AIII modulates synaptic strength and neuronal protein expression. Cell. 2007 Jul 13;130(1):179-91. PubMed.
  2. Zalfa F, Eleuteri B, Dickson KS, Mercaldo V, De Rubeis S, Di Penta A, Tabolacci E, Chiurazzi P, Neri G, Grant SG, Bagni C. A new function for the fragile X mental retardation protein in regulation of PSD-95 mRNA stability. Nat Neurosci. 2007 May;10(5):578-87. PubMed.
  3. Hayashi ML, Rao BS, Seo JS, Choi HS, Dolan BM, Choi SY, Chattarji S, Tonegawa S. Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A. 2007 Jul 3;104(27):11489-94. PubMed.

Further Reading

No Available Further Reading