Antibody

CREB phos Ser133

Tools

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Clonality: polyclonal
Host: Rabbit
Isotype: IgG
Methods: EMSA, IH, IP, WB
Source: Upstate and Chemicon are Millipore
Cat# 06-519
References:
Puzzo, 2009
Trinchese, 2008
Formulation: liquid, PBS, BSA, azide, Protein A/affinity purified
Reactivity:
Reacts in: Human, Hamster, Mouse, Rat

Immunogen/Epitope

Immunogen = synthetic phospho-peptide corresponding to residues 123-136 of rat CREB coupled to KLH

Specificity

recognizes 43 kDa CREB phosphorylated at Ser133. May also recognize phosphorylated CREM (p30) and ATF-1 (p38)

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References

Paper Citations

  1. . Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci. 2009 Jun 24;29(25):8075-86. PubMed.
  2. . Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.

Further Reading

No Available Further Reading