Methods: EMSA, IH, IP, WB
Source: Upstate and Chemicon are Millipore
Formulation: liquid, PBS, BSA, azide, Protein A/affinity purified
Reacts in: Human, Hamster, Mouse, Rat
Immunogen = synthetic phospho-peptide corresponding to residues 123-136 of rat CREB coupled to KLH
recognizes 43 kDa CREB phosphorylated at Ser133. May also recognize phosphorylated CREM (p30) and ATF-1 (p38)
- Puzzo D, Staniszewski A, Deng SX, Privitera L, Leznik E, Liu S, Zhang H, Feng Y, Palmeri A, Landry DW, Arancio O. Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model. J Neurosci. 2009 Jun 24;29(25):8075-86. PubMed.
- Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.
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