Antibody

Aβ[4-10] and APPβ (W0-2)

Tools

Back to the Top

Clonality: monoclonal
Host: Mouse
Isotype: IgG2a
Methods: ELISA, WB
Source: Genetics Company, Inc.
Cat# AB02
References:
(unspecified formulation for:
Richter L, 2010
Wakabayashi, 2009
Serneels, 2009
Minkeviciene, 2009)
Adlard, 2008
Runtz, 2002
Lichtenthaler, 2002
Formulation: supernatant IgG, Tris, azide, affinity purified<br />Also available Biotin or peroxidase conjugated
Reactivity:
Reacts in: Human

Immunogen/Epitope

N-terminal:
Epitope mapping corr. to amino acid residues 4-10 of human Aβ-peptide

Specificity

High affinity to the N-terminal of human Amyloid β peptides Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 and Aβ 1-44

Comments / Questions

Make a comment or submit a question

To make a comment you must login or register.

Comments on this content

No Available Comments

References

Paper Citations

  1. . Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. PubMed.
  2. . Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol. 2009 Nov;11(11):1340-6. PubMed.
  3. . gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. PubMed.
  4. . Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci. 2009 Mar 18;29(11):3453-62. PubMed.
  5. . Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron. 2008 Jul 10;59(1):43-55. PubMed.
  6. . Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci. 2002 Mar 1;22(5):1679-89. PubMed.
  7. . The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. PubMed.

Further Reading

News

  1. That Touch of Pink1—Toning Mitochondrial Respiration
  2. Pink Mutations Link Parkinson’s Disease to Mitochondria
  3. Research Brief: A Swell Protein—Mitochondrial Fission Falls to Pink1, Again
  4. Pink Fission—Serving Up a Rationale for Parkinson Disease?