Antibody

1-40 (2G3)

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Clonality: monoclonal
Host: Mouse
Methods: ELISA
Source: amyloid-beta 40
(Johnson -Wood,
Athena Neurosciences Co, San Francisco, CA
papers:
Citron, et al. PNAS, Nov. 12, 1996, and Johnson-Wood, et al. PNAS, Feb. 18, l997)
References:
Okereke, 2009
Li, 2009
Serneels, 2009
Brody, 2008
Shankar, 2008
DeMatos, 2001,
Buttini, 2002

Immunogen/Epitope

immunogen = the peptide NH2-CYS-NH-CH2-(CH2)5-CO-GLMVGGVV-COOH coupled to sheep anti-mouse IgG

Specificity

amyloid-beta 40 (recognizes amino acids 33-40);no cross-reactivity with Aβ1–42

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References

Paper Citations

  1. . Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Arch Neurol. 2009 Oct;66(10):1247-53. PubMed.
  2. . Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25;62(6):788-801. PubMed.
  3. . gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 1;324(5927):639-42. Epub 2009 Mar 19 PubMed.
  4. . Amyloid-beta dynamics correlate with neurological status in the injured human brain. Science. 2008 Aug 29;321(5893):1221-4. PubMed.
  5. . Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug;14(8):837-42. PubMed.
  6. . Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8850-5. PubMed.
  7. . Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci. 2002 Dec 15;22(24):10539-48. PubMed.

External Citations

  1. Citron, et al.
  2. Johnson-Wood, et al

Further Reading

No Available Further Reading