Methods: FA, WB
Graduate School of Medicine, University of Tennessee Medical Center, Knoxville, TN)
Reacts in: Human, Mouse
raised against sonicated amyloid fibrils grown from synthesized Aβ1–40 peptides (epitope at Aβ residues 5–8)
detects amyloid-beta fibrils; exhibits Ab binding to fibrils in the presence of a large excess of Aβ(1–40) monomer, suggesting that Ab is directed against conformational epitopes that only exist in the fibril
- Villemagne VL, Perez KA, Pike KE, Kok WM, Rowe CC, White AR, Bourgeat P, Salvado O, Bedo J, Hutton CA, Faux NG, Masters CL, Barnham KJ. Blood-borne amyloid-beta dimer correlates with clinical markers of Alzheimer's disease. J Neurosci. 2010 May 5;30(18):6315-22. PubMed.
No Available Further Reading