Antibody

Aβ 42 (G2-11)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, WB
Source: Genetics Company, Inc.
Cat# AB11
References:
Tampellini, 2007
Runtz, 2002
Lichtenthaler, 2002
(both, unspecified formulation)
Formulation: liquid, supernatant, PBS, azide, affinity purified
Reactivity:
Reacts in: Dog, Human, Guinea Pig, Mouse, Rat, Cynomolgus

Immunogen/Epitope

C-terminal epitope mapping corr. to amino acid residues 33-42 of human Aβ peptide

Specificity

reacts with Aβ-peptide, aa 33-42; not Aβ 1-38, Aβ 1-39, Aβ 1-40, Aβ 1-43 or Aβ 1-44

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References

Paper Citations

  1. . Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem. 2007 Jun 29;282(26):18895-906. PubMed.
  2. . Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells. J Neurosci. 2002 Mar 1;22(5):1679-89. PubMed.
  3. . The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. PubMed.

Further Reading