Antibody

Aβ 42, C-terminal

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Clonality: monoclonal
Host: Mouse
Source: JRF/cAβ42/26
(Marc Mercken,
Johnson & Johnson Pharm. R&D,
Paper)
References:
Boland, 2010
Trinchese, 2008
Mi, 2007
Razmahel, 2002
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the carboxy terminal 10 residues of Ab1-42

Specificity

amyloid-beta 42, C-terminus

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References

Paper Citations

  1. Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem. 2010 Nov 26;285(48):37415-26. PubMed.
  2. Trinchese F, Fa' M, Liu S, Zhang H, Hidalgo A, Schmidt SD, Yamaguchi H, Yoshii N, Mathews PM, Nixon RA, Arancio O. Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.
  3. Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy E. Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PubMed.
  4. Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St George-Hyslop P. Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14452-7. PubMed.

External Citations

  1. Marc Mercken
  2. Paper

Further Reading