Antibody

Aβ 40, C-terminus

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Clonality: monoclonal
Host: Mouse
Methods: ELISA, WB
Source: JRF/cAβ40/10
(Paul Mathews, New York University, School of Medicine,
Marc Mercken,
Johnson & Johnson Pharm. R&D,
Paper)
References:
Boland, 2010
Trinchese, 2008
Mi, 2007
Razmahel, 2002
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = a peptide corresponding to Aβ residues 36–40 (VGGVV)

Specificity

recognizes the carboxyl terminus of Aβ40; does not detect Aβ1–42 by ELISA or WB, or full-length APP by IP or WB

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References

Paper Citations

  1. . Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem. 2010 Nov 26;285(48):37415-26. PubMed.
  2. . Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest. 2008 Aug;118(8):2796-807. PubMed.
  3. . Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models. Nat Genet. 2007 Dec;39(12):1440-2. PubMed.
  4. . Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14452-7. PubMed.

External Citations

  1. Paul Mathews
  2. Marc Mercken
  3. Paper

Further Reading