Antibody

APP or β-Amyloid (6E10)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1
Methods: ELISA, IH, IP, WB
Source: Covance Research Products, Inc (now BioLegend)
Cat# SIG-39320
References:
Kitazume, 2010
Fitz, NF, 2010
Davis, 2010 all, unspecified formulation,
Ho, 2009
Kim, 2007
Stamer, 2002
Cai, 2006
Kojro, 2006
Formulation: protein-G purified, PBS, no preservatives or carrier proteins
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

epitope lies within amino acids 3-8 of beta amyloid (EFRHDS)

Specificity

reactive to aa 1-16 Aβ and to APP; reacts to the abnormally processed isoforms, as well as precursor forms

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References

Paper Citations

  1. . Brain endothelial cells produce amyloid {beta} from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form. J Biol Chem. 2010 Dec 17;285(51):40097-103. PubMed.
  2. . Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice. J Neurosci. 2010 May 19;30(20):6862-72. PubMed.
  3. . Deletion of M1 muscarinic acetylcholine receptors increases amyloid pathology in vitro and in vivo. J Neurosci. 2010 Mar 24;30(12):4190-6. PubMed.
  4. . Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. J Neurosci. 2008 Dec 31;28(53):14392-400. PubMed.
  5. . BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 2007 Jul;9(7):755-64. PubMed.
  6. . Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol. 2002 Mar 18;156(6):1051-63. PubMed.
  7. . Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40. PubMed.
  8. . The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein. FASEB J. 2006 Mar;20(3):512-4. PubMed.

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