Antibody

APP cleaved at Asp664 (5A3)

Tools

Back to the Top

Clonality: polyclonal
Host: Rabbit
Methods: ELISA, IP, WB
Source: APPNeo
(Dr. Dale Bredesen, Buck Institute for Age Research)
Paper,
Paper
Reference:
Banwait, 2008
Formulation: affinity purified, borate buffer
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the peptide 657CIHHGVVEVD664, which includes the nine amino acids immediately preceding the caspase cleavage site at position 664 in AβPP, coupled to KLH

Specificity

recognizes the neo-epitope generated by cleavage of AβPP at Asp664 in its intracellular, C-terminal domain; recognizes APP that was truncated at Asp664 but not intact APP

Comments / Questions

Make a comment or submit a question

To make a comment you must login or register.

Comments on this content

No Available Comments

References

Paper Citations

  1. . C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb;13(1):1-16. PubMed.

External Citations

  1. Dr. Dale Bredesen
  2. Paper
  3. Paper

Further Reading

No Available Further Reading