Methods: ELISA, IP, WB
(Dr. Dale Bredesen, Buck Institute for Age Research)
Formulation: affinity purified, borate buffer
Reacts in: Human, Mouse
immunogen = the peptide 657CIHHGVVEVD664, which includes the nine amino acids immediately preceding the caspase cleavage site at position 664 in AβPP, coupled to KLH
recognizes the neo-epitope generated by cleavage of AβPP at Asp664 in its intracellular, C-terminal domain; recognizes APP that was truncated at Asp664 but not intact APP
- Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis. 2008 Feb;13(1):1-16. PubMed.
No Available Further Reading