Antibody

APP

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Clonality: polyclonal
Host: Rabbit
Methods: IH, IP
Source: anti-APP 369
(Sam Gandy,
Mount Sinai Alzheimer's Disease Research Center, NYC)
References:
Lane RF, 2010
Vieira SI, 2010
Pavlov PF, 2010
Li H, 2010
Gandy, 2010
Zhang, 2009
Liu, Y, 2009
Hoe, 2009
Tampellini, 2007
White, 2006
Puglielli, 2001
Li, 2003
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = entire cytoplasmic tail of APP
(paper)

Specificity

C-terminal APP

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References

Paper Citations

  1. . Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. J Neurosci. 2010 Sep 29;30(39):13110-5. PubMed.
  2. . Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener. 2010;5:40. PubMed.
  3. . Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein. FASEB J. 2011 Jan;25(1):78-88. PubMed.
  4. . Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17362-7. PubMed.
  5. . Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Ann Neurol. 2010 Aug;68(2):220-30. PubMed.
  6. . A functional mouse retroposed gene Rps23r1 reduces Alzheimer's beta-amyloid levels and tau phosphorylation. Neuron. 2009 Nov 12;64(3):328-40. PubMed.
  7. . Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1. J Biol Chem. 2009 May 1;284(18):12145-52. PubMed.
  8. . Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. J Neurosci. 2009 Jun 10;29(23):7459-73. PubMed.
  9. . Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations. J Biol Chem. 2007 Jun 29;282(26):18895-906. PubMed.
  10. . Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. J Biol Chem. 2006 Jun 30;281(26):17670-80. PubMed.
  11. . Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct;3(10):905-12. PubMed.
  12. . Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):259-64. PubMed.

External Citations

  1. Sam Gandy
  2. paper

Further Reading

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