Antibody

Amyloid fibrils and fibrillar oligomers

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Clonality: polyclonal
Host: Rabbit
Methods: DB, ELISA, IH, WB
Source: OC
(paper on antibodies;
paper on oligimerization;
Charles G Glabe, University of California, Irvine)
References:
Lefterov, 2010
Clinton, 2010
Blurton-Jones, 2009
Formulation: serum
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogern = a morphologically homogeneous population of Aβ42 fibrils

Specificity

specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers; also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly

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References

Paper Citations

  1. . Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice. J Biol Chem. 2010 Nov 19;285(47):36945-57. PubMed.
  2. . Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. J Neurosci. 2010 May 26;30(21):7281-9. PubMed.
  3. . Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13594-9. PubMed.

External Citations

  1. paper on antibodies
  2. paper on oligimerization
  3. Charles G Glabe

Further Reading

No Available Further Reading