Methods: DB, ELISA, IH, WB
(paper on antibodies;
paper on oligimerization;
Charles G Glabe, University of California, Irvine)
Reacts in: Human
immunogern = a morphologically homogeneous population of Aβ42 fibrils
specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers; also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly
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No Available Further Reading