Antibody

Amyloid beta/A4 (6F/3D)

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Clonality: monoclonal
Host: Mouse
Isotype: IgG1κ
Methods: ELISA, IC
Source: Dako
cat# M0872
References:
Ryu, 2009
Leinonen, 2008
Houlden, 2008
Bacskai, 2007
Mastrianni, 2001
Formulation: liquid, supernat, Tris, azide
Reactivity:
Reacts in: Human

Immunogen/Epitope

immunogen = synthetic peptide consisting of residues 8-17 amyloid beta protein/ amyloid A4, with additional C-terminal cysteine coupled to KLH

Specificity

targets an extracellular amyloid beta-protein/ amyloid A4 in plaques and vessel amyloid

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References

Paper Citations

  1. . Microglial VEGF receptor response is an integral chemotactic component in Alzheimer's disease pathology. J Neurosci. 2009 Jan 7;29(1):3-13. PubMed.
  2. . Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol. 2008 Oct;65(10):1304-9. PubMed.
  3. . Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat Genet. 2007 Dec;39(12):1434-6. PubMed.
  4. . Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar;64(3):431-4. PubMed.
  5. . Inherited prion disease caused by the V210I mutation: transmission to transgenic mice. Neurology. 2001 Dec 26;57(12):2198-205. PubMed.

Further Reading