Host: Unknown Host
Source: (William L. Klein, Ph.D. Professor of Neurobiology & Physiology, Cognitive Neurology and Alzheimer's Disease Center Northwestern University Institute for Neuroscience
Mary P. Lambert, et al, "Monoclonal antibodies that target pathological assemblies of Aβ" full text)
Clones were selected for the
ability to discriminate Alzheimer's disease from control brains in extracts and tissue sections. Epitope found in assemblies
of Abeta1-28 and ADDLs but not in other sequences, including
recognize Abeta oligomers and fibrils but not the physiologically prevalent Abeta monomer. Immuno- neutralization experiments showed that toxicity and attachment of ADDLs to synapses in culture could be prevented. ADDL-induced reactive oxygen species (ROS) generation was also inhibited
- Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem. 2007 Jan;100(1):23-35. PubMed.
- Peng S, Garzon DJ, Marchese M, Klein W, Ginsberg SD, Francis BM, Mount HT, Mufson EJ, Salehi A, Fahnestock M. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. J Neurosci. 2009 Jul 22;29(29):9321-9. PubMed.
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