Antibody

acetylated Tau /ac-tau

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Clonality: polyclonal
Host: Rabbit
Methods: WB
Source: 9AB
Li Gan, Gladstone Institute of Neurological Disease Assistant Professor of Neurology University of California, San Francisco
Reference:
Min SW, 2010
Reactivity:
Reacts in: Human, Mouse

Immunogen/Epitope

immunogen = the microtubule-binding region aa 264–287 (ENLKHQPGGG VQIINKLDLSNV), which is 100% conserved between mouse and human

Specificity

9AB recognizes recombinant tau acetylated by GST-p300, but not tau incubated with GST alone, suggesting that 9AB does not cross-react with non-ac-tau. 9AB also preferentially recognizes p300-induced ac-tau in cultured cells. In mouse brains, 9AB detected low levels of ac-tau. Does not recognize nonacetylated recombinant tau

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References

Paper Citations

  1. . Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 2010 Sep 23;67(6):953-66. PubMed.

External Citations

  1. Li Gan

Further Reading

No Available Further Reading