Antibody

4E-BP1 phos Thr37/46

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Clonality: polyclonal
Host: Rabbit
Source: Cell Signaling
Cat# 9459
Reference:
Hoeffer, 2008
Formulation: liquid, protein-A and affinity purified, HEPES, saline, BSA, glycerol
Reactivity:
Reacts in: Human, Monkey, Mouse, Rat

Immunogen/Epitope

immunogen = synthetic phospho-peptide (KLH-coupled) corresponding to residues surrounding Thr37 and Thr46 of mouse 4E-BP1

Specificity

detects endogenous levels of 4E-BP1 only when phosphorylated at Thr37 and/or Thr46; may cross-react with 4E-BP2 and 4E-BP3 when phosphor. at equivalent sites

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References

Paper Citations

  1. Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10;60(5):832-45. PubMed.

Further Reading

No Available Further Reading