About AlzBiomarker

Versioning History

AlzBiomarker version 1.0 was released December 2015 and meta-analysis results of the initial dataset have been published (Olsson et al., 2016).  Version 1.1 was released April 2016 adding neurogranin data and analyses. Version 1.2 was released June 2016 adding sTREM2. Most recently, version 2.0 was released April 26, 2017. The database will continue to evolve over time with additional data, analyses, biomarkers, and disease cohorts.

The table below presents summary data from the previous version of the database (1.2) and the current version (2.0). Archived pdfs of version 1.2 forest plots are available by clicking on the links in the meta-analysis column.

 

  version 1.2 (June 2016) version 2.0 (April 2017)  
AD vs CTRL # comparisons effect Size p value # comparisons effect size p value meta-analysis
Albumin Ratio (CSF/Serum/Plasma) 20 1.100 0.035 21 1.103 0.02564 v1.2, v2.0
Aβ38 (CSF) 8 0.992 0.891 11 0.955 0.29345 v1.2, v2.0
Aβ40 (CSF) 25 0.945 0.019 32 0.928 0.00056 v1.2, v2.0
Aβ40 (Plasma and Serum) 21 1.044 0.167 26 1.065 0.02803 v1.2, v2.0
Aβ42 (CSF) 142 0.561 <0.0001 168 0.559 <0.0001 v1.2, v2.0
Aβ42 (Plasma and Serum) 22 1.040 0.321 27 1.031 0.38718 v1.2, v2.0
GFAP (CSF) 2 1.119 0.734 2 1.119 0.73555 v1.2, v2.0
hFABP (CSF) 5 1.394 <0.0001 5 1.394 <0.0001 v1.2, v2.0
hFABP (Plasma and Serum) 2 1.049 0.692 2 1.049 0.69241 v1.2, v2.0
MCP-1 (CSF) 3 1.121 <0.0001 5 1.123 <0.0001 v1.2, v2.0
MCP-1 (Plasma and Serum) 6 0.999 0.986 6 0.999 0.98639 v1.2, v2.0
neurogranin (CSF) 10 1.937 <0.0001 10 1.937 <0.0001 v1.2, v2.0
neurogranin (Plasma) 2 0.714 0.253 2 0.714 0.25272 v1.2, v2.0
NFL (CSF) 9 2.351 <0.0001 10 2.313 <0.0001 v1.2, v2.0
NSE (CSF) 7 1.470 0.014 7 1.470 0.01358 v1.2, v2.0
NSE (Plasma and Serum) 3 0.999 0.992 3 0.999 0.99192 v1.2, v2.0
sAPPα (CSF) 9 1.032 0.554 11 1.026 0.55842 v1.2, v2.0
sAPPβ (CSF) 10 1.018 0.605 12 1.020 0.54244 v1.2, v2.0
sTREM2 (CSF) 6 1.272 <0.0001 6 1.272 <0.0001 v1.2, v2.0
tau-phospho (CSF) 96 1.882 <0.0001 116 1.882 <0.0001 v1.2, v2.0
tau-total (CSF) 164 2.535 <0.0001 188 2.480 <0.0001 v1.2, v2.0
tau-total (Plasma and Serum) 6 1.948 0.018 8 1.788 0.00550 v1.2, v2.0
VLP-1 (CSF) 4 1.457 <0.0001 8 1.355 <0.0001 v1.2, v2.0
YKL-40 (CSF) 6 1.285 <0.0001 14 1.291 <0.0001 v1.2, v2.0
YKL-40 (Plasma) 3 1.950 0.053 3 1.950 0.05309 v1.2, v2.0
MCI-AD vs MCI-Stable # comparisons effect Size p value # comparison effect size p value meta-analysis
Aβ38 (CSF) - - - 2 1.127 0.01000 v2.0
Aβ40 (CSF) 3 0.984 0.715 4 1.010 0.81940 v1.2, v2.0
Aβ40 (Plasma) 3 1.066 <0.0001 3 1.066 0.00020 v1.2, v2.0
Aβ42 (CSF) 12 0.674 <0.0001 19 0.663 <0.0001 v1.2, v2.0
Aβ42 (Plasma) 3 0.807 0.324 3 0.807 0.32403 v1.2, v2.0
neurogranin (CSF) 4 1.542 0.003 4 1.542 0.00299 v1.2, v2.0
sAPPα (CSF) 3 1.091 0.195 3 1.091 0.19510 v1.2, v2.0
sAPPβ (CSF) 3 1.055 0.586 3 1.055 0.58568 v1.2, v2.0
tau-phospho (CSF) 9 1.719 <0.0001 13 1.677 <0.0001 v1.2, v2.0
tau-total (CSF) 12 1.758 <0.0001 19 1.730 <0.0001 v1.2, v2.0
YKL-40 (CSF) - - - 3 1.271 <0.0001 v2.0