Can the Heat Shock Response Rescue Muscles and Motor Neurons?
Activating this endogenous protective pathway mops up protein deposits in models of movement disorders. The strategy has advanced to trials.
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Activating this endogenous protective pathway mops up protein deposits in models of movement disorders. The strategy has advanced to trials.
Poly(GA) encoded by C9 repeats incite proteasome and nucleocytoplasmic transport problems, but no TDP43 aggregation.
In several AD mouse models, Aβ caused complement proteins to move to synapses, triggering microglia to eat the structures.
Knocking out neuronal heparan sulfate proteoglycans slashed plaque load and facilitated Aβ clearance in AD model mice.
The modified protein prevents the synaptic protein KIBRA from managing plasticity.
An FDA panel recommended the drug for approval, which would make it the first antipsychotic cleared for use in a neurodegenerative disease.
At Athens meeting, scientists had new data on where these species appear in the brain, how they disrupt neurons, and whether oligo-specific antibodies would work.
Study improves confidence in three core biomarkers and five emerging markers, most in cerebrospinal fluid and one in blood.
Thirteen “escapees” of childhood illness offer hope of finding protective variants that may pay dividends.
Vervet monkeys that model type 1 diabetes have early markers of Alzheimer’s in their brains, providing possible insights on the connection between the two diseases.
Alois was right: Among cognitively normal middle-aged people followed for more than a decade, memory worsened only in those in whom markers for both amyloid and tau were abnormal.
A NOVA special gets up close and personal with Alzheimer’s researchers and their patients, asking if this disease can be stopped.
Scientists report that the transcription factor NRF2 regulates tau expression, stimulating production of a protective isoform.
Neurogeneticists honored for their discoveries, especially of repeat expansions that cause ALS/FTD.
NAPA's latest collective exercise was a conference to update the field on progress in the past three years and advise the NIH on how to spend the next round of funds.
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