New C9ORF72 Antibodies Find Isoforms in Different Cellular Locations
The protein normally comes in long and short isoforms, which hang out in the cytoplasm and on the nuclear envelope, respectively.
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The protein normally comes in long and short isoforms, which hang out in the cytoplasm and on the nuclear envelope, respectively.
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Three studies report that the C9ORF72 expansion prevents RNAs and proteins from shuttling properly between nucleus and cytosol.
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