Don’t Smell the Reaper: Waning Olfaction a Harbinger of Death?
People who lose their sense of smell have triple the odds of dying within five years. Some speculate neurodegenerative disease is involved.
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Does Progranulin in Microglia Protect Against Alzheimer’s?
In mouse models, removing this growth factor only from immune cells worsened pathology and memory.
Synuclein Oligomers: Is EnSNAREing Synaptic Vesicles Their True Calling?
Two studies claim that α-synuclein multimers have a physiological role as wranglers of synaptic vesicles. They come to different conclusions on the finer points, but could they fit into one grand model?
Evidence Mounts That Mitochondrial Gene Is Bona Fide ALS, FTD Risk Factor
Scientists have published 11 instances of mutations in the mitochondrial protein CHCHD10 that contribute to ALS, ALS-FTD, and myopathy.
Cellular Biosensor Detects Tau Seeds Long Before They Sprout Pathology
A new assay detects tau and α-synuclein seeds in human brain samples. Could it become a diagnostic?
Do Neurotrophin and ApoE Together Exacerbate Alzheimer's?
A study claims that two genetic variants combined may hasten cognitive decline in people who have Aβ deposits in the brain.
Lilly Teams Up With AstraZeneca for BACE Inhibitor Phase 2/3 Trial
The pharma giant puts up funding to help develop AstraZeneca’s inhibitor, the second such compound to enter Phase 2 testing.
ALS, Parkinson’s Proteins Co-Mingle in Mitochondria Destruction Pathway
ALS-linked optineurin works closely with Parkinson’s-associated Pink1 and parkin in a pathway that recycles mitochondria.
Phase 2 Trial Hints Idalopirdine May Work as Adjunct Therapy in Alzheimer’s
Results suggest the drug boosts cognition when given alongside the acetylcholinesterase inhibitor.
Alzheimer’s in a Dish? Aβ Stokes Tau Pathology in Third Dimension
Amyloid plaques and tau tangles sprout in human neuron cultures grown in a supportive gel. Researchers think this system may closely model human disease and aid in drug discovery.
Forget Mice—Are Human Cells Better for Drug Testing?
Therapeutics that target γ-secretase produced different results in human neurons and mouse models of Alzheimer’s disease.
More Data, More Progress: ALS Researchers Debut Shared Database
Introducing a clinical trials database for ALS that encompasses nearly 9,000 patient records, the organizers tease with the first few findings.
Stopping Familial Alzheimer's—Woman at Risk Has Healthy Twins
Using a rarely implemented in vitro fertilization procedure, a woman whose family carries a presenilin mutation delivered twins who are virtually assured of escaping early onset Alzheimer’s disease.
Can Monkeys Model Alzheimer’s Better than Rodents?
Aβ oligomers rapidly seed tau pathology in macaques, potentially providing a model for drug testing that better reflects human pathology.Aβ oligomers rapidly seed tau pathology in macaques, potentially providing a model for drug testing that better reflects human pathology.
Wake Up and Smell the … Orexin? Peptide Percolates in Alzheimer’s Brain
People with moderate to severe Alzheimer’s have higher levels of orexin, a neuropeptide that keeps people awake, a study reports. The findings solidify links between orexin and sleep disturbances associated with the disease.
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