Limited Protein Shapes May Explain Drug Side Effects
A new study explains why many drugs come with similar side effects...
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Alzheimer’s Disease Snags High-Profile Prize
The focus of the next XPRIZE is Alzheimer’s disease...
G8 to Set Sights on Dementia
This June, leaders from the globe’s eight richest countries, the G8, will assemble to discuss major economic issues—among them, the rising threat of dementia in aging populations...
Does Shrinking Temporal Lobe Make AD Patients Overly Sensitive?
Though typically seen as a cognitive disorder, Alzheimer’s disease can throw emotions off kilter, making people unusually sensitive to others’ feelings and moods...
Single-Blind Trial: Diabetes Drug Helps Parkinson’s, Maybe
Could an approved diabetes medication treat Parkinson’s disease?...
Methylation a Turn Off for Disease Gene C9ORF72?
Since the discovery of nucleotide repeats in the C9ORF72 gene, the hexanucleotides have presented a puzzle for scientists...
Brain Changes Speak Volumes About Normal Aging and Dementia
Brain atrophy plagues more than just people with neurodegenerative disorders...
Newborn Neurons Abundant in Adult Human Hippocampus
Using carbon-14 to estimate the age of neurons, researchers calculate that the human brain produces around 700 new neurons per day...
Mouse Brain Circulatory System Knows No Bounds
Tiny blood vessels in the mouse brain crisscross the cortex, passing from one neural column to the next, like multiple streets between interconnecting city blocks...
Genotype-Based Meta-Analysis Suggests Serum Iron Protects Against PD
Though iron gets a bad rap for accumulating in the brains of older people and individuals with neurodegenerative disease, could an abundance of this metal in the blood bode well?
Building a Roadmap for Shared Combination Drug Trials
As potential AD drugs continue to post disappointing Phase 2/3 results, many in the field are considering upping the artillery by testing experimental drugs in combination.
DSM-5: Debated? Yes. Important for AD Diagnosis? Maybe Not
After more than a decade in the works, the long-awaited fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) arrived last month to little fanfare.
In Familial AD, Aβ Production Up, Clearance Down
Researchers have long assumed that people with familial Alzheimer’s disease make too much Aβ42 in the brain, but they lacked proof.
Lilly Halts Phase 2 Trial of BACE Inhibitor Due to Liver Toxicity
Eli Lilly and Company announced yesterday that they have terminated the Phase 2 trial of their BACE inhibitor LY2886721 due to liver abnormalities.
Immune Cell Receptor Gives Aβ a Toxic Edge
Despite ample evidence implicating Aβ in Alzheimer’s pathology, scientists still struggle to understand how the peptide harms the brain.
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