Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
A new project to identify factors that allow some carriers of pathogenic mutations to escape their genetic destinies could be applicable to neurodegenerative diseases.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
People with Alzheimer’s disease and other dementias may benefit from creative activities, but hard studies are still lacking.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
Deep-brain stimulation of the nucleus basalis of Meynert appeared safe and tolerable for Alzheimer’s patients.
Allegations of scientist misconduct led to the retraction of one high-profile stem cell paper and put two others in doubt.
Tirasemtiv, a drug thought to make muscles more sensitive to signals from motor neurons, failed to improve muscle function in people with amyotrophic lateral sclerosis.