An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
A small molecule inhibitor kills all microglia in the brain, but the cells rapidly repopulate from a previously unidentified progenitor cell.
Allegations of scientist misconduct led to the retraction of one high-profile stem cell paper and put two others in doubt.
A new study charges that, contrary to previous studies, seeding the mouse brain with aggregated α-synuclein does not trigger a toxic spread of PD-like inclusions in wild-type mice.
Nucleotide repeat expansions in the C9ORF72 gene occur in amyotrophic lateral sclerosis and frontotemporal dementia. Now researchers find the same repeats in patients with two other neurological disorders.
New research suggests that dendritic tau may participate in synaptic plasticity, and that Aβ disrupts this function.