Scientists have turned a yeast heat shock protein into a powerful disaggregase that attacks TDP-43, FUS, and α-synuclein mutants.
A man lacking ApoE appears to have no cognitive deficits, and his brain and CSF biomarker profiles appear normal. Some claim the findings support ApoE as a rational drug target for AD.
Researchers pumped gel and detergents through rodents to make their entire bodies clear. The new technique will allow scientists to image cells throughout the body.
Could exosomes—tiny parcels extruded from cells—make for a blood-based Alzheimer’s marker?
Repeat peptides made by the mutant C9ORF72 gene in ALS and FTD enter the nucleolus and obstruct RNA biogenesis.
Researchers are ramping up efforts to target tau for Alzheimer’s and other tauopathies.
The first large-scale surveys of DNA methylation in Alzheimer’s brains turned up numerous altered regions that may point to new genes involved in pathology.
Perfectly healthy mitochondria can sicken neurons simply by being in the wrong place.
A global effort to combat dementia has been conducting a yearlong series of events. Alzforum spoke with Dennis Gillings, who chairs the new World Dementia Council.
Researchers will have full access to a gargantuan genetic meta-analysis on the newly revamped PDGene database.
New data strengthens the evidence that dementia risk is dropping in developed countries, possibly due to better education and heart health.
In mouse models, Aβ aggregates injected into the belly invade the brain, as do prion seeds.
Lifestyle changes to evade dementia, such as healthy eating and exercise, made a strong showing at the Alzheimer’s Association International Conference in Copenhagen, Denmark.
Signals emanating from the prefrontal cortex play a role in forming memories in the hippocampus, a study reports. The finding could have implications for Alzheimer’s.
Researchers have modeled a motor neuron in silico to show how energy shortage could lead to its degeneration in amyotrophic lateral sclerosis.