Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
Head injury increases one’s chances of future dementia by 60 percent, according to a study in veterans.
Engaging in cognitive activities throughout life staves off decline. It also delays Aβ accumulation, two studies report.
The largest meta-analysis done to date confirms dramatic variability in age at onset of autosomal-dominant Alzheimer's disease overall, but finds mutation type and parental age at onset to be strong predictive modulators.
Some macrophages use their dying breath to emit a distress signal that could spell trouble for their neighbors.
Could astrocyte neurotransmission explain memory loss in Alzheimer's disease?
Aβ aggregates can assume a variety of structures that appear to have unique properties.
Allosteric γ-secretase modulator binds an extracellular pocket on presenilin, changing the active site.
Blocking calcium-dependent protease normalizes lifespan in mouse tauopathy model.
Heart-healthy foods containing omega-3 fatty acids, like salmon, slash risk of developing ALS by one-third.
Researchers are looking to the eye for a cheap, easy way to detect Alzheimer’s pathology in the brain.
A novel mutation frays mitochondrial DNA and impedes ATP synthesis in people with an ALS-FTD-like syndrome.
Several thousand people have used preimplantation genetic diagnosis to avoid passing on pathogenic mutations to their babies, but many families with a history of Alzheimer’s or related diseases remain unaware of this option.
Families considering PGD to avoid passing on disease genes face obstacles such as high cost and invasive procedures.