In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
Alpha-secretase does not necessarily pick up the slack when β-secretase cleavage of amyloid precursor protein wanes, a study in primates finds. It suggests APP can be processed in other ways.
A new project to identify factors that allow some carriers of pathogenic mutations to escape their genetic destinies could be applicable to neurodegenerative diseases.
X-ray crystallography reveals secrets of the glutamate receptor.
While mice sleep, neurons sprout synapses to solidify fresh skills, according to a new study. The brain also keeps amyloid-β levels low while we snooze.
Belying some earlier reports, a new study finds that grafted dopamine cells continue to innervate neural networks years after transplantation.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
A candidate reference method for measuring Aβ42 in cerebrospinal fluid brings researchers closer to standardization.
In award-winning documentary, son traces his mother’s progression into Alzheimer’s disease.
Playing nursemaid, TGF-β helps new neurons in the brain survive, develop, and migrate.
Researchers link frontotemporal dementia pathology to DNA damage.
Big-data project takes on Alzheimer's with a biomarker computational challenge.
AFFiRiS AG claims that a placebo formulation, not their active Aβ vaccine, slowed the progression of Alzheimer's disease in a Phase 2 study.
The ADCS–PACC, a new cognitive composite test to be used in the A4 prevention trial, detects subtle deficits in older adults with brain amyloid.
A close-up of the protein mayhem within the synaptic bouton offers scientists an unprecedented glimpse of the activity inside.