In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
An antibody against ApoE helps clear plaques and improves cognition in AD model mice.
Conformations of misfolded tau survive injection from one mouse to the next, a property shared by prions.
A single dose of a commonly prescribed antidepressant suppresses Aβ production in the human central nervous system.
People with Alzheimer’s disease and other dementias may benefit from creative activities, but hard studies are still lacking.
X-ray crystallography reveals secrets of the glutamate receptor.
While mice sleep, neurons sprout synapses to solidify fresh skills, according to a new study. The brain also keeps amyloid-β levels low while we snooze.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.
A new project to identify factors that allow some carriers of pathogenic mutations to escape their genetic destinies could be applicable to neurodegenerative diseases.
Will an antibody signature make for a new Alzheimer’s diagnostic?
By paring back calcium signaling, researchers prevented signs of Alzheimer’s in mice carrying a presenilin mutation. Could the strategy work in humans?
MetLife rewards research on secretases, toxic Aβ transmission.
New twist to fluorescence-based microscopy lets scientists see up-close how Aβ aggregates in living cells.
A candidate reference method for measuring Aβ42 in cerebrospinal fluid brings researchers closer to standardization.
In award-winning documentary, son traces his mother’s progression into Alzheimer’s disease.