In mouse models, the Alzheimer’s risk gene TREM2 affects microglial behavior but does not lead to more amyloid deposition.
An antibody against ApoE helps clear plaques and improves cognition in AD model mice.
Scientists report that astrocytes help neurons destroy their unwanted mitochondria.
Tau and amyloid PET tracers demonstrate potential to sharpen the diagnosis of Alzheimer’s disease and frontotemporal dementias.
Alpha-secretase does not necessarily pick up the slack when β-secretase cleavage of amyloid precursor protein wanes, a study in primates finds. It suggests APP can be processed in other ways.
Conformations of misfolded tau survive injection from one mouse to the next, a property shared by prions.
Plenty of genetic risk factors for sporadic ALS are still waiting to be found, according to a new meta-analysis of GWAS data.
Mutated huntingtin may stow away in synaptic vesicles to sneak from one neuron to another.
A single dose of a commonly prescribed antidepressant suppresses Aβ production in the human central nervous system.
Deep-brain stimulation of the nucleus basalis of Meynert appeared safe and tolerable for Alzheimer’s patients.
Death receptor role in Alzheimer's disease looks less likely than was originally thought following a high-profile paper in 2009.
People with Alzheimer’s disease and other dementias may benefit from creative activities, but hard studies are still lacking.
A new project to identify factors that allow some carriers of pathogenic mutations to escape their genetic destinies could be applicable to neurodegenerative diseases.
X-ray crystallography reveals secrets of the glutamate receptor.
An amplification-based test picks up minute amounts of prion protein in the blood of asymptomatic carriers, but researchers wonder whether regulators will want to screen the population.